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CDK12 ligand-3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-177786
    CDK12 ligand-3

    		Molecular Glues CDK Cancer
    CDK12 ligand-3 is a molecular glucose degrading agent that targets the CDK12 protein (DC50 = 35 nM). CDK12 ligand-3 degrades CDK12, CDK13 and their regulatory subunit Cyclin K in a concentration dependent manner, and inhibits RNA polymerase II CTD (Ser2) phosphorylation. CDK12 ligand-3 exhibits potent anti proliferative activity against Jurkat cells. CDK12 ligand-3 can be used for research on cancers such as leukemia .
    CDK12 ligand-3

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