2. PROTAC Cell Cycle/DNA Damage
  3. Molecular Glues CDK
  4. CDK12 ligand-3

CDK12 ligand-3 is a molecular glucose degrading agent that targets the CDK12 protein (DC50 = 35 nM). CDK12 ligand-3 degrades CDK12, CDK13 and their regulatory subunit Cyclin K in a concentration dependent manner, and inhibits RNA polymerase II CTD (Ser2) phosphorylation. CDK12 ligand-3 exhibits potent anti proliferative activity against Jurkat cells. CDK12 ligand-3 can be used for research on cancers such as leukemia.

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CDK12 ligand-3

CDK12 ligand-3 Chemical Structure

CAS No. : 3093763-27-7

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CDK12 ligand-3 Related Antibodies

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Description

CDK12 ligand-3 is a molecular glucose degrading agent that targets the CDK12 protein (DC50 = 35 nM). CDK12 ligand-3 degrades CDK12, CDK13 and their regulatory subunit Cyclin K in a concentration dependent manner, and inhibits RNA polymerase II CTD (Ser2) phosphorylation. CDK12 ligand-3 exhibits potent anti proliferative activity against Jurkat cells. CDK12 ligand-3 can be used for research on cancers such as leukemia[1].

Molecular Weight

514.04

Formula

C25H28ClN5O3S
CAS No.
SMILES

ClC1=CN=C(N[C@H]2CN(CCC2)C(C3=CC=CC=C3)=O)N=C1NC4=CC=CC=C4S(=O)(C(C)C)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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CDK12 ligand-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK12 ligand-33093763-27-7Molecular GluesCDKCyclin dependent kinaseCDK12molecular gluesCDK13JurkatleukemiaInhibitorinhibitorinhibit

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