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Results for "

Blm

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111756
    BLM-IN-1

    		Apoptosis Cancer
    BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer .
    BLM-IN-1
  • HY-12342
    ML216
    5+ Cited Publications

    CID-49852229

    		 DNA/RNA Synthesis Cancer
    ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLM full-length and BLM 636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 μM. Antitumor avtivity .
    ML216
  • HY-128712
    NCGC00029283

    		DNA/RNA Synthesis Cancer
    NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .
    NCGC00029283
  • HY-P3239
    Belantamab mafodotin

    GSK2857916; Belantamab mafodotin-Blm

    		 Antibody-Drug Conjugates (ADCs) Cancer
    Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. The antibody portion is Belantamab (HY-P9980), and the drug-linker conjugate for ADC is McMMAF (HY-15578). Belantamab mafodotin has anti-myeloma activity .
    Belantamab mafodotin
  • HY-110185
    NSC 617145
    2 Publications Verification

    		 DNA/RNA Synthesis Cancer
    NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .
    NSC 617145
  • HY-151939
    BLM-IN-2

    		DNA/RNA Synthesis Apoptosis Cancer
    BLM-IN-2 is a Bloom's Syndrome Protein (BLM) inhibitor with an IC50 value of 0.8 μM. BLM-IN-2 effectively suppresses the proliferation, invasion, cell cycle arrest and apoptosis of CRC cells. BLM-IN-2 can be used for the reserarch of colorectal cancer (CRC) .
    BLM-IN-2
  • HY-RS23038
    Blm Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Blm Rat Pre-designed siRNA Set A contains three designed siRNAs for Blm gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Blm Rat Pre-designed siRNA Set A
    Blm Rat Pre-designed siRNA Set A
  • HY-RS01520
    BLM Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    BLM Human Pre-designed siRNA Set A contains three designed siRNAs for BLM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    BLM Human Pre-designed siRNA Set A
    BLM Human Pre-designed siRNA Set A
  • HY-RS16604
    Blm Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Blm Mouse Pre-designed siRNA Set A contains three designed siRNAs for Blm gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Blm Mouse Pre-designed siRNA Set A
    Blm Mouse Pre-designed siRNA Set A
  • HY-173483
    ATX inhibitor 26

    		Phosphodiesterase (PDE) ERK JNK p38 MAPK Inflammation/Immunology
    ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. ATX inhibitor 26 inhibits cell migration and collagen gel contraction. ATX inhibitor 26 has significant anti-fibrotic effects, reducing collagen deposition in a Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis model .
    ATX inhibitor 26
  • HY-156420
    ATUX-1215

    		Phosphatase Apoptosis Inflammation/Immunology Cancer
    ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals. ATUX-1215 can slow the progression of lung fibrosis .
    ATUX-1215
  • HY-176194
    Antifibrotic agent 1

    		Collagen c-Fms PDGFR Src Inflammation/Immunology
    Antifibrotic agent 1 is an orally active anti-idiopathic pulmonary fibrosis (IPF) agent. Antifibrotic agent 1 effectively attenuates IPF-related processes, including TGF-β induced EMT and FMT processes, as well as pro-fibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α and Src family kinases (SFKs), while sparing VEGFRs, FGFRs and Abl to minimize off-target toxicity. Antifibrotic agent 1 has potent anti-fibrotic activity in Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice model .
    Antifibrotic agent 1
  • HY-175033
    BRD4-IN-11

    		Epigenetic Reader Domain Phosphatase c-Myc Apoptosis Inflammation/Immunology
    BRD4-IN-11 is an orally active and selective BRD4 inhibitor (IC50 = 26.35 nM (BD1), IC50 = 72.81 nM (BD2)). BRD4-IN-11 is approximately 3- to 18-fold more potent against BRD4 than against BRr2, BRD3, and BRDT. BRD4-IN-11 enhances H2S release and inhibits the upregulation of fibrotic markers (α-SMA and fibronectin), c-Myc, and CDC25B. BRD4-IN-11 reduces apoptosis in LO2 hepatocytes. BRD4-IN-11 significantly improves liver and lung function in a hepatopulmonary fibrosis model and can be used to study hepatopulmonary fibrosis .
    BRD4-IN-11

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