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Results for "

BMX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BMX Kinase (4) Apoptosis (2) Arf Family GTPase (1) Autophagy (1) Btk (6) EGFR (1) Reactive Oxygen Species (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (8) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Targets Recommended: BMX Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-80002

BMX-IN-1 5 Publications Verification BMX kinase inhibitor	Btk BMX Kinase	Cancer
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys ⁴⁹⁶ in the BMX ATP binding domain with an IC₅₀ of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

HY-130574

MnTE-2-PyP chloride BMX-010 chloride	Reactive Oxygen Species	Cancer
MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer .

HY-101267

*CHMFL-BMX-078* 1 Publications Verification CHMFL-BMX 078	BMX Kinase	Cancer
CHMFL-BMX-078 is a highly potent and selective type II irreversible *BMX* kinase inhibitor with an IC₅₀ of 11 nM.

HY-173057

BMX-IN-3	BMX Kinase Apoptosis Autophagy	Cancer
BMX-IN-3 (B6a) is an irreversible and selective *BMX* inhibitor, with an IC₅₀ of 12 nM. BMX-IN-3 (B6a) promots cell cycle arrest and apoptosis, triggers protective autophagy, and suppresses the BMX/AKT/mTOR pathway. BMX-IN-3 (B6a) can be used in the research for Gastric Carcinoma .

HY-125662A

BMX-001	Reactive Oxygen Species Apoptosis	Metabolic Disease
BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. BMX-001 reduces apoptosis in human and murine islets. BMX-001 significantly improves static-glucose stimulated insulin secretion (sGSIS) responses in murine islets. BMX-001 can significantly restore euglycemia in murine islet studies in the presence of the MnSOD. BMX-001 reduces the generation of ROS in a murine islet isolation and culture model .

HY-RS01558

Bmx Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bmx Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmx gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmx Mouse Pre-designed siRNA Set A Bmx Mouse Pre-designed siRNA Set A

HY-RS01559

Bmx Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bmx Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmx gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmx Rat Pre-designed siRNA Set A Bmx Rat Pre-designed siRNA Set A

HY-RS01557

BMX Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMX Human Pre-designed siRNA Set A contains three designed siRNAs for BMX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMX Human Pre-designed siRNA Set A BMX Human Pre-designed siRNA Set A

HY-148585

BTK-IN-22	Btk	Cancer
BTK-IN-22 is a BTK inhibitor (IC₅₀: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC₅₀s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib (HY-10997)

HY-148594

BTK-IN-23	Btk	Cancer
BTK-IN-23 is a BTK inhibitor (IC₅₀: 12.8 nM). BTK-IN-23 also inhibits BLX and *BMX* with IC₅₀s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997) .

HY-117900A

(Rac)-PF-06250112	Btk	Inflammation/Immunology
(Rac)-PF-0625011 is a racemate of PF-06250112. PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor and shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC .

HY-117900

PF-06250112	Btk	Inflammation/Immunology
PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC₅₀ of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC₅₀s of 0.9 nM and 1.2 nM, respectively .

HY-173280

Brefeldin A 4-O-nicotinate CHNQD-01228	Arf Family GTPase BMX Kinase	Cancer
Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and *BMX* proteins. The IC₅₀ value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the *BMX* protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer .

HY-145373

BMS-986143	Btk	Inflammation/Immunology
BMS-986143 is an orally active, reversible BTK inhibitor with an IC₅₀ of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1, ITK with IC₅₀s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM,19 nM, 21 nM, respectively. BMS-986143 can be used for the research of autoimmune diseases .

HY-111553

TAS0728	EGFR	Cancer
TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC₅₀ of 13 nM. TAS0728 also shows IC₅₀s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for *BMX、HER4、BLK、EGFR、JAK3、SLK* and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701711

	BMX Protein, Human (Sf9) BMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38	Human	Sf9 insect cells
	BMX proteins are nonreceptor tyrosine kinases that centrally regulate various signaling pathways that control actin dynamics, migration, proliferation, and survival. BMX participates in signal transduction of multiple receptors such as integrins, growth factor receptors, and cytokine receptors, induces BCAR1 tyrosine phosphorylation, and plays a key role in TNF-induced angiogenesis. BMX Protein, Human (Sf9) is the recombinant human-derived BMX protein, expressed by Sf9 insect cells , with tag free.

HY-P701712

	BMX Protein, Human (Sf9, His) BMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38	Human	Sf9 insect cells
	BMX proteins are nonreceptor tyrosine kinases that centrally regulate various signaling pathways that control actin dynamics, migration, proliferation, and survival. BMX participates in signal transduction of multiple receptors such as integrins, growth factor receptors, and cytokine receptors, induces BCAR1 tyrosine phosphorylation, and plays a key role in TNF-induced angiogenesis. BMX Protein, Human (Sf9, His) is the recombinant human-derived BMX protein, expressed by Sf9 insect cells , with N-8*His labeled tag.

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Bmx Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bmx Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmx gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bmx Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bmx Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmx gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMX Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BMX Human Pre-designed siRNA Set A contains three designed siRNAs for BMX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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