BCG

By Targets:	Antibiotic (1) Aryl Hydrocarbon Receptor (2) Autophagy (2) Bacterial (9) ERK (2) MEK (2) Small Interfering RNA (siRNA) (2) TNF Receptor (1)
By Research Areas:	Cancer (4) Infection (8) Inflammation/Immunology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6624

Skullcapflavone II	Bacterial	Inflammation/Immunology
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG .

HY-N15644

Mycolic acid IIa	Bacterial	Infection
Mycolic acid IIa is a structural lipid component of mycobacterial cell wall. Mycolic acid IIa can be isolated from Mycobacterium bovis BCG. Mycolic acid IIa significantly modulates membrane permeability and stability, promising for mycobacterium tuberculosis infection research .

HY-P6312

ESAT6 Epitope	Bacterial	Infection
ESAT6 Epitope is a known CD4+ T cell epitope in early secretory antigen target gene 6 (ESAT6) that binds to major histocompatibility complex MHC class I with nanometer affinity (IC₅₀=180 nM). ESAT6 Epitope can be used to enhance BCG-induced anti-Mycobacterium tuberculosis cellular immunity .

HY-173355

RCB18350	Bacterial	Infection
RCB18350 is an antituberculosis agent that belongs to the class of isoxazole derivatives. RCB18350 has bacteriostatic activity and inhibits the growth of Mycobacterium tuberculosis with an MIC of 1.25 μg/mL. RCB18350 is effective against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) clinical isolates, slow-growing mycobacteria such as Mycobacterium bovis BCG and Mycobacterium avium .

HY-N12600

Thiolopyrrolone A	Bacterial	Infection
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .

HY-173617

GDI-5755 SAM002706100	Bacterial	Infection Inflammation/Immunology
GDI-5755, an antibacterial agent by inhibiting ClpP1P2, inhibits the growth of Mtb and M. bovis BCG, the model organism of mycobacteria. GDI-5755 can be used in the research for tuberculosis (TB) .

HY-RS26047

Slc11a1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Slc11a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc11a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc11a1 Rat Pre-designed siRNA Set A Slc11a1 Rat Pre-designed siRNA Set A

HY-N11048

Amycolatopsin A	Bacterial	Infection Cancer
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-172462

Mtb-IN-11	Bacterial	Infection
Mtb-IN-11 (Compound 1e) is an inhibitor of Mycobacterium tuberculosis salicylate synthase (MbtI), with an IC₅₀ of 11.2 μM. Mtb-IN-11 exhibits good in vitro anti-tuberculosis activity, with a MIC₉₉ of 32 μM against M. bovis BCG. Mtb-IN-11 can be used for the research of tuberculosis .

HY-P991525

2141-V11	TNF Receptor	Cancer
2141-V11 is an anti-CD40 agonist antibody with enhanced binding to FcγRIIB. 2141-V11 results in effective tumor-specific T-cell responses in vivo. 2141-V11 can be used for the study of BCG-unresponsive non-muscle invasive bladder cancer .

HY-146098

Antibacterial agent 105	Bacterial Antibiotic	Infection
Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC₉₀=2.64 μM). Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC₉₀s of 11.18, 11.18, 0.70, 1.40, 44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum, BCG, E. aerogenes and S. aureus, respectively .

HY-RS19551

Slc11a1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Slc11a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc11a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc11a1 Mouse Pre-designed siRNA Set A Slc11a1 Mouse Pre-designed siRNA Set A

HY-12028

PD98059 350+ Cited Publications	MEK ERK Aryl Hydrocarbon Receptor Autophagy	Cancer
PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and MEK2 (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and AHR transformation (IC₅₀ of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

HY-12028R

PD98059 (Standard)	MEK ERK Aryl Hydrocarbon Receptor Autophagy	Cancer
PD98059 (Standard) is the analytical standard of PD98059. This product is intended for research and analytical applications. PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

Cat. No.	Product Name	Target	Research Area

HY-P6312

ESAT6 Epitope	Bacterial	Infection
ESAT6 Epitope is a known CD4+ T cell epitope in early secretory antigen target gene 6 (ESAT6) that binds to major histocompatibility complex MHC class I with nanometer affinity (IC₅₀=180 nM). ESAT6 Epitope can be used to enhance BCG-induced anti-Mycobacterium tuberculosis cellular immunity .

Cat. No.	Product Name	Target	Research Area

HY-P991525

2141-V11	TNF Receptor	Cancer
2141-V11 is an anti-CD40 agonist antibody with enhanced binding to FcγRIIB. 2141-V11 results in effective tumor-specific T-cell responses in vivo. 2141-V11 can be used for the study of BCG-unresponsive non-muscle invasive bladder cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6624

Skullcapflavone II	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Bacterial
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG .

HY-N15644

Mycolic acid IIa	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Mycolic acid IIa is a structural lipid component of mycobacterial cell wall. Mycolic acid IIa can be isolated from Mycobacterium bovis BCG. Mycolic acid IIa significantly modulates membrane permeability and stability, promising for mycobacterium tuberculosis infection research .

HY-N12600

Thiolopyrrolone A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Bacterial
Thiolopyrrolone A (compound 1) exhibits antibacterial activities against BCG, M. tuberculosis and S. aureus with minimum inhibitory concentrations (MIC) of 10, 10 and 100 μg/mL, respectively .

HY-N11048

Amycolatopsin A	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

Cat. No.	Product Name		Classification

HY-RS26047

Slc11a1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Slc11a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc11a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19551

Slc11a1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Slc11a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc11a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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