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Results for "

Artemisinin

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

1

Screening Libraries

11

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0094
    Artemisinin
    Maximum Cited Publications
    25 Publications Verification

    Qinghaosu; NSC 369397

    		 HCV Parasite Akt Ferroptosis Infection Neurological Disease Cancer
    Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin
  • HY-B0094R
    Artemisinin (Standard)

    Qinghaosu (Standard); NSC 369397 (Standard)

    		 Reference Standards HCV Parasite Akt Ferroptosis Infection Neurological Disease Cancer
    Artemisinin (Standard) is the analytical standard of Artemisinin. This product is intended for research and analytical applications. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin (Standard)
  • HY-N8801
    Anhydrodihydro artemisinin

    		Others Others
    Anhydrodihydro artemisinin is a Sesquiterpene product .
    Anhydrodihydro artemisinin
  • HY-16762
    Artefenomel
    2 Publications Verification

    OZ439

    		 Parasite Ferroptosis SARS-CoV Infection
    Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2 .
    Artefenomel
  • HY-W585869
    Amorphadiene

    		Parasite Infection
    Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast .
    Amorphadiene
  • HY-B0094S
    Artemisinin-d3

    Qinghaosu-d3; NSC 369397-d3

    		 Akt Ferroptosis HCV Parasite Infection Neurological Disease Cancer
    Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin-d3
  • HY-B0094S3
    Artemisinin-13C,d4

    Qinghaosu-13C,d4; NSC 369397-13C,d4

    		 Ferroptosis Akt Parasite HCV Isotope-Labeled Compounds Infection Neurological Disease Cancer
    Artemisinin- 13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin-13C,d4
  • HY-W587751
    Arteannuic alcohol

    Amorpha-4,11-diene-12-ol

    		 Drug Intermediate Infection
    Arteannuic alcohol (Amorpha-4,11-diene-12-ol) is a precursor substance in the biosynthetic pathway of Artemisinin (HY-B0094). Alcohol dehydrogenase catalyzes the dehydrogenation reaction of chlorogenic alcohol to produce artemisinic aldehyde .
    Arteannuic alcohol
  • HY-16762R
    Artefenomel (Standard)

    		Parasite Ferroptosis SARS-CoV Infection
    Artefenomel (Standard) is the analytical standard of Artefenomel. This product is intended for research and analytical applications. Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2 .
    Artefenomel (Standard)
  • HY-175498
    RLA-3107

    		SARS-CoV Infection
    RLA-3107 is an artemisinin regioisomer that blocks ion channels, thereby preventing cations from entering the host cytoplasm. RLA-3107 is also a viroporin inhibitor .
    RLA-3107
  • HY-B1896A
    Piperaquine phosphate

    		Parasite Infection
    Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .
    Piperaquine phosphate
  • HY-B1896B
    Piperaquine tetraphosphate tetrahydrate

    		Parasite Infection
    Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin .
    Piperaquine tetraphosphate tetrahydrate
  • HY-W013331
    Deoxyartemisinin
    1 Publications Verification

    2-DeoxyArtemisinin

    		 Others Inflammation/Immunology
    Deoxyartemisinin, a orally bioavailable compound separated from Artemisinin annua L., shows anti-inflammatory and antiulcer activities .
    Deoxyartemisinin
  • HY-B1896
    Piperaquine

    		Parasite Infection
    Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin .
    Piperaquine
  • HY-137553A
    β-Aminoarteether maleate

    SM934

    		 NOD-like Receptor (NLR) Inflammation/Immunology
    β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases .
    β-Aminoarteether maleate
  • HY-N1667R
    2',4'-Dihydroxy-6'-Methoxyacetophenone (Standard)

    		Parasite Infection
    2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. Artemisia annua is an analog of Artemisinin that is effective in the research of malaria .
    2',4'-Dihydroxy-6'-Methoxyacetophenone (Standard)
  • HY-N1667
    2',4'-Dihydroxy-6'-Methoxyacetophenone

    		Parasite Infection
    2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. Artemisia annua is an analog of Artemisinin that is effective in the research of malaria .
    2',4'-Dihydroxy-6'-Methoxyacetophenone
  • HY-137553
    β-Aminoarteether

    SM934 free base

    		 NOD-like Receptor (NLR) Inflammation/Immunology
    β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases .
    β-Aminoarteether
  • HY-B1896AR
    Piperaquine phosphate (Standard)

    		Parasite Infection
    Piperaquine (phosphate) (Standard) is the analytical standard of Piperaquine (phosphate). This product is intended for research and analytical applications. Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .
    Piperaquine phosphate (Standard)
  • HY-B1896BR
    Piperaquine tetraphosphate tetrahydrate (Standard)

    		Parasite Infection
    Piperaquine (tetraphosphate tetrahydrate) (Standard) is the analytical standard of Piperaquine (tetraphosphate tetrahydrate). This product is intended for research and analytical applications. Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin .
    Piperaquine tetraphosphate tetrahydrate (Standard)
  • HY-W129233
    Dihydroartemisinin (mixture of α and β isomers)

    DihydroArtemisinin (α,β mixture)

    		 Parasite Autophagy Apoptosis Infection Cancer
    Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress .
    Dihydroartemisinin (mixture of α and β isomers)
  • HY-106848
    Arteflene

    Ro 42-1611

    		 Parasite Infection
    Arteflene is a synthetic structural analogue of artemisinin. Arteflene has antimalarial activity .
    Arteflene
  • HY-N4106
    Dihydroartemisinic acid

    Dihydroqinghao acid

    		 Parasite Ferroptosis Infection
    Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin (HY-B0094) .
    Dihydroartemisinic acid
  • HY-172131
    Emoquine-1

    		Parasite Infection
    Emoquine-1 is an orally active and potent antimalarial drug. Emoquine-1 is efficient against multidrug-resistant Plasmodium parasites, including the Artemisinin-resistant quiescent stage. Emoquine-1 is active against proliferative P. falciparum with IC50 values of 20-55 nM. Emoquine-1 is a candidate to fight Plasmodium parasites resistant to artemisinin-based combination therapies (ACTs) with a capacity to eliminate persistent parasites .
    Emoquine-1
  • HY-B1896S
    Piperaquine-d6

    		Parasite Infection
    Piperaquine-d6 is the deuterium labeled Piperaquine . Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin .
    Piperaquine-d6
  • HY-122550
    Artemisitene
    3 Publications Verification

    		 Keap1-Nrf2 Topoisomerase Apoptosis Cancer
    Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability .
    Artemisitene
  • HY-118865S
    Piperaquine-d6 tetraphosphate

    		Isotope-Labeled Compounds Parasite Infection
    Piperaquine-d6 (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin .
    Piperaquine-d6 tetraphosphate
  • HY-135578
    Artelinic acid

    		Parasite Infection
    Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .
    Artelinic acid
  • HY-132931
    TCMDC-125457

    		Parasite Infection
    TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
    TCMDC-125457
  • HY-N1984
    Artemisic acid

    Qing Hao acid; Artemisinic acid; Arteannuic acid

    		 JNK Interleukin Related Infection Metabolic Disease Inflammation/Immunology Cancer
    Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect .
    Artemisic acid
  • HY-N1457
    Chrysosplenetin
    1 Publications Verification

    		 P-glycoprotein Cytochrome P450 Ferroptosis Metabolic Disease
    Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A .
    Chrysosplenetin
  • HY-149428
    AD4
    1 Publications Verification

    		 PROTACs Cancer
    AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .
    AD4
  • HY-111817
    ACT-451840

    		Parasite Infection
    ACT-451840 is an orally active, potent and low-toxicity compound, showing activity against sensitive and resistant plasmodium falciparum strains. ACT-451840 targets all asexual blood stages of the parasite, has a rapid onset of action. ACT-451840 behaves in a way similar to artemisinin derivatives, with very rapid onset of action and elimination of parasite. ACT-451840 can be used for the research of malarial .
    ACT-451840
  • HY-N1984R
    Artemisic acid (Standard)

    Qing Hao acid (Standard); Artemisinic acid (Standard); Arteannuic acid (Standard)

    		 Reference Standards JNK Interleukin Related Infection Metabolic Disease Inflammation/Immunology Cancer
    Artemisic acid (Standard) (Qing Hao acid (Standard)) is the analytical standard of Artemisic acid (HY-N1984). This product is intended for research and analytical applications. Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect .
    Artemisic acid (Standard)
  • HY-170999
    Antitumor agent-196

    		Caspase Apoptosis Ferroptosis Cancer
    Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer activity, showing an IC50 of 90 nM against MCF-7 breast cancer cells. Antitumor agent-196 promotes Apoptosis by regulating the Bax-caspase 3 signaling pathway, and induces Ferroptosis through the modulation of key signaling molecules, including GPX4. Antitumor agent-196 holds promising potential for further research in the field of cancer therapy .
    Antitumor agent-196
  • HY-175221
    WHN-11

    		Apoptosis Autophagy Cancer
    WHN-11 is an amino-Artemisinin (HY-B0094) derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC) .
    WHN-11
  • HY-111817A
    (Rac)-ACT-451840

    		Parasite Infection
    (Rac)-ACT-451840 is an isomer of ACT-451840 that exhibits significant antimalarial effects. (Rac)-ACT-451840 exhibits significant antimalarial activity against P. berghei-infected mice at a dose of 20 mg/kg (ED90=13 mg/kg), and has an inhibitory effect at a dose of 300 mg/kg. The ED90 of (Rac)-ACT-451840 in the P. falciparum humanized immunodeficient mouse model is 3.7 mg/kg. (Rac)-ACT-451840 is similar to artemisinin, with a rapid onset of action but requires repeated high doses.
    (Rac)-ACT-451840

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