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AURKB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (1) Aurora Kinase (11) c-Met/HGFR (1) CDK (1) EGFR (1) Ephrin Receptor (1) FGFR (1) IRAK (1) Itk (1) Ligands for Target Protein for PROTAC (1) MAP4K (1) MELK (1) Mps1 (2) p38 MAPK (1) Polo-like Kinase (PLK) (2) PROTACs (4) Small Interfering RNA (siRNA) (3) ULK (1) VEGFR (1) Wee1 (1)
By Research Areas:	Cancer (11)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157480

*EGFR/AURKB-IN-1*	EGFR Aurora Kinase	Cancer
EGFR/AURKB-IN-1 (compound 7) is a dual-targeted *EGFR/AURKB* inhibitor, and inhibits the phpsphorylations of ^L858R EGFR and AURKB with IC₅₀s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research .

HY-151971

Aurora kinase-IN-3 1 Publications Verification	Aurora Kinase Polo-like Kinase (PLK)	Cancer
Aurora kinase-IN-3 (Compound 15a) is an orally active *AURKB* inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10 .

HY-148065

FMF-06-098-1	PROTACs Wee1 CDK AAK1 ULK MELK Itk IRAK Ephrin Receptor FGFR MAP4K p38 MAPK	Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 (Pink: target protein ligand (HY-169396); Blue: VHL ligand (HY-112078); Black: Linker (HY-124380)) .

HY-RS01270

AURKB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Aurora Kinase	Others
AURKB Human Pre-designed siRNA Set A contains three designed siRNAs for AURKB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AURKB Human Pre-designed siRNA Set A AURKB Human Pre-designed siRNA Set A

HY-RS01271

Aurkb Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Aurora Kinase	Others
Aurkb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurkb Mouse Pre-designed siRNA Set A Aurkb Mouse Pre-designed siRNA Set A

HY-RS01272

Aurkb Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Aurora Kinase	Others
Aurkb Rat Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurkb Rat Pre-designed siRNA Set A Aurkb Rat Pre-designed siRNA Set A

HY-168543

PROTAC MPS1 degrader 2	PROTACs Aurora Kinase Mps1	Cancer
PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1，TTK)，AURKA and *AURKB*，with DC₅₀s of 42.0，2.1 and 154.0 nM，respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984) .

HY-168540

PROTAC MPS1 degrader 1	PROTACs Mps1 Aurora Kinase	Cancer
PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and *AURKB, with DC₅₀*s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984) .

HY-175525

MS44	PROTACs Aurora Kinase	Cancer
MS44 is a potent aurora kinase B (AURKB PROTAC) degrader (DC₅₀ = 103 nM). MS44 effectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner and is selective for AURKB over AURKA and AURKC. MS44 effectively inhibits the proliferation in multiple cancer cell lines and potently induces G2/M arrest. MS44 can be used for the study of AURKB-dependent tumors (Pink: Target protein ligand (HY-175526); Blue: E3 ligand (HY-112078); Black: Linker; E3 ligand + Linker (HY-132938)) .

HY-175526

Aurora kinase ligand-1	Ligands for Target Protein for PROTAC Aurora Kinase	Cancer
Aurora kinase ligand-1 (Compound I-4) is an Aurora kinase B (AURKB) PROTAC ligand. Aurora kinase ligand-1 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize AURKB PROTAC degrader MS44 (HY-175525). MS44 can be used for cancer reasearch .

HY-123610

BRD-7880	Aurora Kinase	Cancer
BRD-7880 is a potent and highly specific inhibitor of Aurora Kinase B (AURKB) and Aurora Kinase C (AURKC), with IC₅₀ values of 7 nM and 12 nM, respectively .

HY-176191

Aurora kinase-IN-7	Aurora Kinase	Cancer
Aurora kinase-IN-7 (compound 4b) is an orally active and selective *AURKB* inhibitor. Aurora kinase-IN-7 can be used in the study of aggressive cancers .

HY-120279A

CFI-400437	Polo-like Kinase (PLK)	Cancer
CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC₅₀ of 0.6 nM) .

HY-10338A

Foretinib phosphate	c-Met/HGFR VEGFR	Cancer
Foretinib phosphate is an orally bioavailable small molecule with potential anti-tumor activity. Foretinib phosphate can selectively inhibit hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), thereby potentially inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. Foretinib phosphate shows different anti-cancer activity from cabozantinib in lung cancer cells and has stronger inhibitory effects on targets such as MEK1/2, FER and AURKB .

Cat. No.	Compare	Product Name	Species	Source

HY-P704867

	AURORA B Protein, Human (Active, sf9, GST) AURKB; AIK2; AIM1; ARK2; AurB; IPL1; AIM-1; STK12	Human	Sf9 insect cells

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HY-P80562

	Aurora B Antibody (YA594) AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12	WB, IP	Human
	Aurora B Antibody (YA594) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aurora B.

HY-P85045

	Aurora B Antibody (YA4737) AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human
	Aurora B Antibody (YA4737) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Aurora B.

HY-P86439

	Aurora B Antibody (YA6131) AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Aurora B Antibody (YA6131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aurora B.

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AURKB Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AURKB Human Pre-designed siRNA Set A contains three designed siRNAs for AURKB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurkb Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Aurkb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Aurkb Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Aurkb Rat Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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