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Results for "

APE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (1) Apelin Receptor (APJ) (1) Apical Sodium-Dependent Bile Acid Transporter (7) Apoptosis (3) Autophagy (3) Biochemical Assay Reagents (1) DNA/RNA Synthesis (7) Estrogen Receptor/ERR (1) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (2) Isotope-Labeled Compounds (5) MDM-2/p53 (1) MMP (2) NF-κB (3) NKCC (4) Parasite (4) Phospholipase (1) PKC (2) Prostaglandin Receptor (1) Reactive Oxygen Species (1) Reference Standards (1) ROCK (2) Sodium Channel (1) TNF Receptor (1) Topoisomerase (1) VEGFR (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (6) Infection (3) Inflammation/Immunology (8) Metabolic Disease (9) Neurological Disease (4)

By Targets:

AP-1 (1)

Apelin Receptor (APJ) (1)

Apical Sodium-Dependent Bile Acid Transporter (7)

Apoptosis (3)

Autophagy (3)

Biochemical Assay Reagents (1)

DNA/RNA Synthesis (7)

Estrogen Receptor/ERR (1)

HIF/HIF Prolyl-Hydroxylase (1)

Interleukin Related (2)

Isotope-Labeled Compounds (5)

MDM-2/p53 (1)

MMP (2)

NF-κB (3)

NKCC (4)

Parasite (4)

Phospholipase (1)

PKC (2)

Prostaglandin Receptor (1)

Reactive Oxygen Species (1)

Reference Standards (1)

ROCK (2)

Sodium Channel (1)

TNF Receptor (1)

Topoisomerase (1)

VEGFR (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (6)

Infection (3)

Inflammation/Immunology (8)

Metabolic Disease (9)

Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals .

HY-136731

APE1-IN-1	DNA/RNA Synthesis	Cancer
APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC₅₀ value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells .

HY-NP014

Protein A-PE	Biochemical Assay Reagents	Others
Protein A-PE is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-126425

NCGC00262650	Parasite	Infection
NCGC00262650 is a potent apical membrane antigen 1-rhoptry neck protein 2 (AMA1-RON2) interaction inhibitor. NCGC00262650 can block entry of merozoites into red blood cells with an IC₅₀ of 9.8 μM .

HY-B2098

Lucanthone	Autophagy Parasite	Cancer
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

HY-149442

APE1-IN-3	DNA/RNA Synthesis	Cancer
APE1-IN-3 (Compound 1) is a *APE1* inhibitor. APE1-IN-3 can be used for the research of cancer .

HY-N3625

Coronalolic acid Coronalonic acid	NF-κB	Inflammation/Immunology
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production .

HY-122521

Sootepin D	NF-κB	Inflammation/Immunology
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity .

HY-15131

PNRI-299	Interleukin Related	Inflammation/Immunology
PNRI-299 is a selective AP-1 transcription inhibitor with an IC₅₀ of 20 uM. PNRI-299 is a selective *APE/Ref-1* inhibitor. PNRI-299 has no effect on NF-κB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model .

HY-B2098A

Lucanthone hydrochloride	Autophagy Parasite	Cancer
Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

HY-133795

Lucanthone N-oxide	DNA/RNA Synthesis	Others
Lucanthone N-oxide is the nitrogen oxide of Lucanthone (HY-B2098), an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .

HY-W014622

CRT0044876 2 Publications Verification	DNA/RNA Synthesis	Cancer
CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC₅₀=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds .

HY-120069

APX2009	Apoptosis	Cancer
APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell .

HY-P5824

Anthopleurin-C	Sodium Channel	Neurological Disease
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

HY-19357

E3330 3 Publications Verification APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Cancer
E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities .

HY-18713

CRT0066854	PKC ROCK	Neurological Disease Inflammation/Immunology
CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-18713A

CRT0066854 hydrochloride	PKC ROCK	Neurological Disease
CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-101190

Volixibat SHP626; LUM002	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH) .

HY-109120

Odevixibat 3 Publications Verification A4250	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-119993

AR03 BMH-23	DNA/RNA Synthesis	Cancer
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC₅₀ of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells .

HY-100210A

FN-439 TFA	MMP	Inflammation/Immunology Cancer
FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation .

HY-100210

FN-439	MMP	Inflammation/Immunology Cancer
FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 can be used for the research of cancer and inflammation .

HY-B1363

Bendroflumethiazide Bendrofluazide	NKCC	Cardiovascular Disease
Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .

HY-167735

Salvizol Bisdequalinium diacetate	Others	Infection
Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.

HY-155774

VU533 1 Publications Verification	Phospholipase	Metabolic Disease
APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC₅₀ value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research .

HY-16643

Linerixibat Maximum Cited Publications 11 Publications Verification GSK2330672	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease Inflammation/Immunology
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC₅₀ of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment .

HY-109120S

Odevixibat-d5 A4250-d₅	Apical Sodium-Dependent Bile Acid Transporter Isotope-Labeled Compounds	Metabolic Disease
Odevixibat-d₅ is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-W338581

4-tert-Octylphenol monoethoxylate	Estrogen Receptor/ERR	Others
4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .

HY-B1099

Hycanthone 2 Publications Verification	DNA/RNA Synthesis Topoisomerase Parasite	Infection
Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K_D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent .

HY-109120S1

Odevixibat-13C6 A4250-¹³C₆	Apical Sodium-Dependent Bile Acid Transporter Isotope-Labeled Compounds	Metabolic Disease
Odevixibat- ¹³C₆ is ¹³C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-135259

CAY10580	Prostaglandin Receptor	Metabolic Disease
CAY10580 is a potent and selective prostaglandin EP₄ receptor agonist (K_i=35 nM) .

HY-129982

SC-435	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .

HY-15790H

(S)-Elobixibat (S)-A 3309; (S)-AZD 7806	Apical Sodium-Dependent Bile Acid Transporter TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology
(S)-Elobixibat is the S enantiomer of Elobixibat (HY-15790). (S)-Elobixibat is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor. (S)-Elobixibat decreases LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. (S)-Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors .

HY-B1363S

Bendroflumethiazide-d5 Bendrofluazide-d₅	Isotope-Labeled Compounds NKCC	Cardiovascular Disease
Bendroflumethiazide-d₅ (Bendrofluazide-d₅) is the deuterium labeled Bendroflumethiazide (HY-B1363).Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .

HY-B1363R

Bendroflumethiazide (Standard) Bendrofluazide (Standard)	NKCC Reference Standards	Cardiovascular Disease
Bendroflumethiazide (Standard) (Bendrofluazide (Standard)) is the analytical standard of Bendroflumethiazide (HY-B1363). This product is intended for research and analytical applications. Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .

HY-B1363S1

Bendroflumethiazide-d7 Bendrofluazide-d₇	Isotope-Labeled Compounds NKCC	Cardiovascular Disease
Bendroflumethiazide-d₇ (Bendrofluazide-d₇) is deuterium labeled Bendroflumethiazide (HY-B1363). Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .

HY-P3347

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)	Apelin Receptor (APJ)	Cardiovascular Disease
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (K_i=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life .

HY-W777582

4-tert-Octylphenol monoethoxylate-13C6	Isotope-Labeled Compounds	Others
4-tert-Octylphenol monoethoxylate- ¹³C₆ is the ¹³C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .

HY-123056A

EAD1 TFA	Autophagy Apoptosis	Others
EAD1 TFA is an aluminum-activated malate transporter with activity in regulating corn ear development. EAD1 TFA is preferentially expressed in the xylem of immature ears and localized across the plasma membrane. The EAD1 TFA transports malic acid in the apical part of developing inflorescences, and its deletion results in reduced malic acid content in this part. The overexpression of EAD1 TFA was significantly positively correlated with ear length and the number of kernels per row. EAD1 TFA serves as a potential genetic resource to help improve grain yield in maize .

Cat. No.	Product Name	Type

HY-NP014

Protein A-PE	Native Proteins
Protein A-PE is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

Cat. No.	Product Name	Target	Research Area

HY-P5824

Anthopleurin-C	Sodium Channel	Neurological Disease
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

HY-100210

FN-439	MMP	Inflammation/Immunology Cancer
FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 can be used for the research of cancer and inflammation .

HY-P3347

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)	Apelin Receptor (APJ)	Cardiovascular Disease
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (K_i=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3625

Coronalolic acid Coronalonic acid	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production .

HY-122521

Sootepin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity .

Species:	Human (2)
Tag:	His (1) Tag Free (1) MBP (1) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7523

	APE Protein, Human rHuAPE; APE1; APEX; APE	Human	E. coli
	APE Protein, Human is an approximately 40.0 kDa protein expressed by E. coli expression system. Human APE plays an important role in BER by acting downstream of DNA glycosylases.

HY-P702038

	SLC20A2 Protein, Human (sf9, His, MBP, FLAG) SLC20A2; Sodium-dependent phosphate transporter 2; Gibbon APE leukemia virus receptor 2; GLVR-2; Phosphate transporter 2; PiT-2; Pit2; hPit2; Solute carrier family 20 member 2	Human	Sf9 insect cells
	The SLC20A2 protein is a sodium-phosphate symporter that transports monovalent phosphate with a stoichiometry of two sodium ions per phosphate ion. Its role in bone mineralization is critical to bone quality and strength. SLC20A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC20A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B1363S

Bendroflumethiazide-d5

Bendroflumethiazide-d₅ (Bendrofluazide-d₅) is the deuterium labeled Bendroflumethiazide (HY-B1363).Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .

HY-109120S

Odevixibat-d5
Odevixibat-d₅ is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-109120S1

Odevixibat-13C6
Odevixibat- ¹³C₆ is ¹³C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-B1363S1

Bendroflumethiazide-d7

Bendroflumethiazide-d₇ (Bendrofluazide-d₇) is deuterium labeled Bendroflumethiazide (HY-B1363). Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus .

HY-W777582

4-tert-Octylphenol monoethoxylate-13C6

4-tert-Octylphenol monoethoxylate- ¹³C₆ is the ¹³C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84226

	APEX1 Antibody (YA3923) APE; APX; APE1; APEN; APEX; HAP1; REF1	WB, IHC-P, FC, ELISA	Human, Rat, Monkey

HY-P82375

	APE1 Antibody (YA2120) APEX1; APE; APE1; APEX; APX; HAP1; REF1; DNA-(apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1	WB	Human, Mouse, Rat
	APE1 Antibody (YA2120) is a non-conjugated IgG antibody, targeting APE1, with a predicted molecular weight of 36 kDa (observed band size: 36 kDa). APE1 Antibody (YA2120) can be used for WB experiment in human, mouse, rat background.