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Results for "

ACTRIIA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (2) TGF-β Receptor (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (1) Metabolic Disease (3)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99355

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human ActRIIB and *ActRIIA*, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .

HY-P99590A

Sotatercept (mIgG2a) RAP-011	TGF-β Receptor TGF-beta/Smad	Cardiovascular Disease Metabolic Disease
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Endocrinology Cancer
LAE-102, a monoclonal antibody, is an activin receptor type II-A (ACTRIIA/ACVR2) antagonist. LAE-102 is promising for research of endocrine and metabolic diseases, tumors, and respiratory system diseases .

HY-RS00246

Acvr2a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Acvr2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acvr2a Mouse Pre-designed siRNA Set A Acvr2a Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P99355

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human ActRIIB and *ActRIIA*, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .

HY-P99590A

Sotatercept (mIgG2a) RAP-011	TGF-β Receptor TGF-beta/Smad	Cardiovascular Disease Metabolic Disease
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Endocrinology Cancer
LAE-102, a monoclonal antibody, is an activin receptor type II-A (ACTRIIA/ACVR2) antagonist. LAE-102 is promising for research of endocrine and metabolic diseases, tumors, and respiratory system diseases .

Recombinant Proteins Recommended:

Activin A Receptor Type 2A (ACTR-IIA)

Species:	Human (4) Mouse (2) Rat (1)
Tag:	His (5) Avi (2) Fc (3)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P75537

	*ACVR2A/Activin RIIA* Protein, Human (HEK293, Fc)** ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2	Human	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134 amino acids (M1-P134).

HY-P75563

	*ACVR2A/Activin RIIA* Protein, Mouse (HEK293, His)** ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2	Mouse	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-P134).

HY-P703683

	RIIA/ACVR2A Protein, Rat (HEK293, His) Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA; Acvr2a; ACTR-IIA	Rat	HEK293
	RIIA/ACVR2A Protein, Rat (HEK293, His) is the recombinant rat-derived RIIA/ACVR2A protein, expressed by HEK293, with C-His tag.

HY-P7455

	*ACVR2A/Activin RIIA* Protein, Human (HEK293, His, solution)** rHuActivin receptor type 2A, His; ACVR-2A; Activin receptor type 2A	Human	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 115 amino acids (A20-P134).

HY-P75562

	*ACVR2A/Activin RIIA* Protein, Mouse (HEK293, His-Fc)** ACVR-2A; Activin receptor type 2A; ACTR-IIA; ACVR2	Mouse	HEK293
	ACVR2A, also known as Activin RIIA, is an activin type II receptor. On ligand binding, ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. ACVR2A is a receptor for Activin A, Activin B and Inhibin A. ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 134 amino acids (M1-P134).

HY-P703977

	*ACVR2A/Activin RIIA* Protein, Human/Cynomolgus (Biotinylated, HEK293, His, Avi)** ACTR-IIA; ACTRIIA; ACVR2A; ACVR2	Human	HEK293
	ACVR2A/Activin RIIA Protein, Human/Cynomolgus (Biotinylated, HEK293, His, Avi) is the recombinant human-derived ACVR2A/Activin RIIA protein, expressed by HEK293, with C-Avi & C-His tag.

HY-P703995

	*ACVR2A/Activin RIIA* Protein, Human/Cynomolgus (Biotinylated, HEK293, hFc, Avi)** ACTR-IIA; ACTRIIA; ACVR2A; ACVR2	Human	HEK293
	ACVR2A/Activin RIIA Protein, Human/Cynomolgus (Biotinylated, HEK293, hFc, Avi) is the recombinant human-derived ACVR2A/Activin RIIA protein, expressed by HEK293, with C-Avi & C-hFc tag.

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HY-P83050

	Activin Receptor Type IIA Antibody (YA2795) ACTR2; ACTRII; ACTRIIA; Acvr2; ACVR2A	WB	Human, Mouse, Rat
	Activin Receptor Type IIA Antibody (YA2795) is a non-conjugated IgG antibody, targeting Activin Receptor Type IIA, with a predicted molecular weight of 58 kDa (observed band size: 85 kDa). Activin Receptor Type IIA Antibody (YA2795) can be used for WB experiment in human, mouse, rat background.

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Acvr2a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Acvr2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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