2. Search Result
Search Result
Results for "

3-Phosphoglycerate dehydrogenase

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Recombinant Proteins

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126278
    Z1609609733

    		Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    Z1609609733 (Compound 18) is a non-covalent 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation .
    Z1609609733
  • HY-125273
    DNS-pE

    		Fluorescent Dye Others
    DNS-pE is a vinyl sulfone-based fluorescent probe that has the activity to selectively label 3-phosphoglycerate dehydrogenase (PHGDH) in living mammalian cells and generate fluorescence after labeling, while having inhibitory properties comparable to those of known inhibitors.
    DNS-pE
  • HY-W552257
    Hydroxypyruvic acid phosphate

    		Phosphatase Others
    Hydroxypyruvic acid phosphate serves as a crucial metabolic intermediate in the biosynthesis of L-Serine, being formed from the conversion of the glycolytic intermediate 3-phosphoglycerate through the action of 3-phosphoglycerate dehydrogenase. Subsequently, it is transformed into phosphoserine by phosphohydroxypyruvate aminotransferase, and finally, via the action of phosphoserine phosphatase, it is converted into L-Serine. This pathway not only highlights the significance of hydroxypyruvic acid phosphate in cellular proliferation but also emphasizes its role in providing essential one-carbon groups necessary for the synthesis of purine nucleotides and deoxythymidine monophosphate, thereby underscoring its metabolic importance in the central nervous system and various physiological conditions.
    Hydroxypyruvic acid phosphate

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: