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12-Nitro-9-cis,12-cis-octadecadienoic acid

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-171895
    12-Nitrolinoleate

    12-Nitro-9-cis,12-cis-octadecadienoic acid

    		 PPAR Interleukin Related NF-κB TNF Receptor Inflammation/Immunology
    12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS .
    12-Nitrolinoleate

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