12-Nitrolinoleate (Synonyms: 12-Nitro-9-cis,12-cis-octadecadienoic acid)

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12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS.}

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12-Nitrolinoleate Chemical Structure

CAS No. : 774603-05-3

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12-Nitrolinoleate Related Antibodies

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Description

12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1]^[2]^[3].}

Molecular Weight
325.44

Formula
C₁₈H₃₁NO₄

CAS No.
774603-05-3

SMILES
OC(CCCCCCC/C=C\C/C([N+]([O-])=O)=C\CCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (266 KB) Handling Instructions (2659 KB)

References

[1]. 12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is a peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1]^[2]^[3].} [Content Brief]

[2]. Baker, P. R., et al., (2004). Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. Proceedings of the National Academy of Sciences of the United States of America, 101(32), 11577–11582. [Content Brief]

[3]. Cui, T., et al., (2006). Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. The Journal of biological chemistry, 281(47), 35686–35698. [Content Brief]

[4]. Alexander, R. L., et al., (2009). Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation. Biochemistry, 48(2), 492–498. [Content Brief]

[1]. 12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is a peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1]^[2]^[3].}

[2]. Baker, P. R., et al., (2004). Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. Proceedings of the National Academy of Sciences of the United States of America, 101(32), 11577–11582.

[3]. Cui, T., et al., (2006). Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. The Journal of biological chemistry, 281(47), 35686–35698.

[4]. Alexander, R. L., et al., (2009). Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation. Biochemistry, 48(2), 492–498.

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12-Nitrolinoleate Related Classifications

Inflammation/Immunology

Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis

PPAR Interleukin Related NF-κB TNF Receptor

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Keywords:

12-Nitrolinoleate774603-05-312-Nitro-9-cis,12-cis-octadecadienoic acidPPARInterleukin RelatedNF-κBTNF ReceptorPeroxisome proliferator-activated receptorsILNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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Description	12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1]^[2]^[3].}
Molecular Weight	325.44
Formula	C₁₈H₃₁NO₄
CAS No.	774603-05-3
SMILES	OC(CCCCCCC/C=C\C/C([N+]([O-])=O)=C\CCCCC)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. 12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is a peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1]^[2]^[3].} [Content Brief] [2]. Baker, P. R., et al., (2004). Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. Proceedings of the National Academy of Sciences of the United States of America, 101(32), 11577–11582. [Content Brief] [3]. Cui, T., et al., (2006). Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. The Journal of biological chemistry, 281(47), 35686–35698. [Content Brief] [4]. Alexander, R. L., et al., (2009). Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation. Biochemistry, 48(2), 492–498. [Content Brief]

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12-Nitrolinoleate (Synonyms: 12-Nitro-9-cis,12-cis-octadecadienoic acid)

12-Nitrolinoleate Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All Interleukin Related Isoform Specific Products:

View All NF-κB Isoform Specific Products:

View All TNF Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

12-Nitrolinoleate Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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Customer Review

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