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Results for "

1,2 diacylglycerol

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

7

Biochemical Assay Reagents

4

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1

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128468
    1,2-Dimyristoyl-sn-glycerol

    		Liposome PKC Parasite Others
    1,2-Dimyristoyl-sn-glycerol is a saturated diacylglycerol and a weak second messenger for the activation of PKC .
    1,2-Dimyristoyl-sn-glycerol
  • HY-128465
    1,2-Dilauroyl-sn-glycerol

    		Endogenous Metabolite Others
    1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction .
    1,2-Dilauroyl-sn-glycerol
  • HY-112552
    1,2-Distearoyl-sn-glycerol

    DSG; 1,2-Dioctadecanoyl-sn-glycerol

    		 Endogenous Metabolite Biochemical Assay Reagents Others
    1,2-Distearoyl-sn-glycerol (DSG) is a glyceride compound. 1,2-Distearoyl-sn-glycerol can be used as an internal standard for the analysis of molecular species of diacylglycerol (DAG) and other phospholipids in rat brain .
    1,2-Distearoyl-sn-glycerol
  • HY-165045
    1,2-Dipentadecanoyl-rac-glycerol

    DG(15:0/15:0/0:0); 1,2-Dipentadecanoin

    		 Endogenous Metabolite Others
    1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound mentioned in the study of the effects of insulin on 1,2-diacylglycerol in rat hearts. Insulin can increase the content of 1,2-diacylglycerol with a specific fatty acid composition in the heart, which may be related to cardiac contractility.
    1,2-Dipentadecanoyl-rac-glycerol
  • HY-115769
    1,2-Didecanoylglycerol

    		PKC Endocrinology
    1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA10) and activates protein kinase C (PKC) [1] .
    1,2-Didecanoylglycerol
  • HY-170470
    1,2-Diarachidoyl-rac-glycerol

    DG(20:0/20:0/0:0)

    		 Biochemical Assay Reagents Others
    1,2-Diarachidoyl-rac-glycerol (DG(20:0/20:0/0:0)) is a diacylglycerol in which both acyl groups are acyl groups of arachidonic acid. 1,2-Diarachidoyl-rac-glycerol can be used to enhance the skin barrier function and maintain the moisture and lipid balance of the skin as a diacylglycerol derivative .
    1,2-Diarachidoyl-rac-glycerol
  • HY-118442
    Sphingosine (d14:1)

    Tetradecasphing-4-enine

    		 PKC Cancer
    Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .
    Sphingosine (d14:1)
  • HY-164112
    1,2-Dioleoyl-sn-glycero-3-(cytidine diphosphate) ammonium

    18:1 CDP DG

    		 Biochemical Assay Reagents Others
    1,2-Dioleoyl-sn-glycero-3-(cytidine diphosphate) ammonium (18:1 CDP DG) is a diacylglycerol derivate .
    1,2-Dioleoyl-sn-glycero-3-(cytidine diphosphate) ammonium
  • HY-128465R
    1,2-Dilauroyl-sn-glycerol (Standard)

    		Endogenous Metabolite Others
    1,2-Dilauroyl-sn-glycerol (Standard) is the analytical standard of 1,2-Dilauroyl-sn-glycerol. This product is intended for research and analytical applications. 1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction .
    1,2-Dilauroyl-sn-glycerol (Standard)
  • HY-170639
    1,2-Diheptadecanoyl-rac-glycerol

    		Biochemical Assay Reagents Metabolic Disease
    1,2-Diheptadecanoyl-rac-glycerol is a diacylglycerol that contains Heptadecanoic acid (HY-W004284) at the sn-1 and sn-2 positions.
    1,2-Diheptadecanoyl-rac-glycerol
  • HY-117115
    1,2-Dihexanoyl-sn-glycerol

    		Biochemical Assay Reagents Others
    1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.
    1,2-Dihexanoyl-sn-glycerol
  • HY-165042
    1,2-Dipalmitoyl-3-decanoyl-rac-glycerol

    1,2-Palmitin-3-caprin; 1,2-Palmitin-3-decanoin; TG(16:0/16:0/10:0)

    		 Others Others
    1,2-Dipalmitoyl-3-decanoyl-rac-glycerol (1,2-Palmitin-3-caprin), a compound mentioned in the chemical analysis of triglycerides and diacylglycerols in bovine milk fat, was identified by a specific chromatography-mass spectrometry technique, which is environmentally friendly and efficient.
    1,2-Dipalmitoyl-3-decanoyl-rac-glycerol
  • HY-165056
    1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol

    1,2-Palmitin-3-linolein; TG(16:0/16:0/18:2)

    		 Others Others
    1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol (1,2-Palmitin-3-linolein), a compound mentioned in the chemical analysis of triglycerides and diacylglycerols in bovine milk fat, was identified by a specific chromatography-mass spectrometry technique, which is environmentally friendly and efficient.
    1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol
  • HY-W127391
    1,2-Dilaurin

    (Rac)-1,2-Didodecanoylglycerol

    		 Biochemical Assay Reagents Others
    1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).
    1,2-Dilaurin
  • HY-105953
    Froxiprost

    ONO-995

    		 Prostaglandin Receptor Endocrinology
    Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells .
    Froxiprost
  • HY-W482407
    1,2-O-Dihexadecyl-sn-glycerol

    (S)-2,3-Bis(hexadecyloxy)propan-1-ol

    		 Biochemical Assay Reagents Metabolic Disease
    1,2-O-Dihexadecyl-sn-glycerol ((S)-2,3-Bis(hexadecyloxy)propan-1-ol) is a saturated dialkyl glyceryl ether with hexadecyl groups at the sn-1 and sn-2 positions that mimics the structure of diacylglycerol.
    1,2-O-Dihexadecyl-sn-glycerol
  • HY-145541
    12-Dinonadecanoyl-rac-glycerol

    1,2-Dinonadecanoin

    		 Biochemical Assay Reagents Others
    12-Dinonadecanoyl-rac-glycerol is a diacylglycerol containing nonadecanoic acid (HY-W004261) at the sn-1 and sn-2 positions. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis to defence .
    12-Dinonadecanoyl-rac-glycerol
  • HY-117168
    1,2-Dilinoleoyl-sn-glycerol

    		Endogenous Metabolite Metabolic Disease
    1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy.
    1,2-Dilinoleoyl-sn-glycerol
  • HY-P2856
    Phosphatidylinositol phosphodiesterase

    		Endogenous Metabolite Metabolic Disease
    Phosphatidylinositol phosphodiesterase hydrolyzes phosphatidylinositol to diacylglycerols and a mixture of myoinositol 1- and 1, 2-cyclic phosphates .
    Phosphatidylinositol phosphodiesterase
  • HY-W100403
    Choline tosylate

    Choline p-toluenesulfonate

    		 Phospholipase Cancer
    Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) [1] .
    Choline tosylate
  • HY-18551
    DAGLβ-IN-1

    		DAGL Inflammation/Immunology
    DAGLβ-IN-1 is an inhibitor of diacylglycerol lipase-β (DAGLβ), serves as a versatile intermediate for the design of DAGL-tailored activity-based probes [1] .
    DAGLβ-IN-1
  • HY-W004260B
    Dieicosanoin

    Glycerol diarachidate

    		 Endogenous Metabolite Biochemical Assay Reagents Others
    Dieicosanoin is a diacylglycerol containing arachidic acid (HY-W004260). Arachidic acid is a saturated long-chain fatty acid with a 20-carbon backbone. Arachidic acid can be isolated from peanut butter and anaerobic fungi [1] .
    Dieicosanoin
  • HY-W010736A
    1,2-Dipalmitoyl-rac-glycerol

    		Biochemical Assay Reagents Others
    1,2-Dipalmitoyl-rac-glycerol is a diacylglycerol containing palmitic acid at the sn-1 and sn-2 positions (Cat. No. 10006627). It is found in a variety of vegetable oils, including palm, soybean, canola, and corn. 1 \n 1,2-Dipalmitoyl-rac-glycerol MaxSpec Standard is a quantitative grade standard of 1,2-dipalmitoyl-rac-glycerol prepared for mass spectrometry and related applications requiring quantitative reproducibility . The solution has been prepared gravimetrically and contained in argon-sealed deactivated glass ampoules. Concentrations were verified by comparison to independently prepared calibration standards. This 1,2-dipalmitoyl-rac-glycerol MaxSpec Standard is guaranteed to meet specifications for identity, purity, stability, and concentration and is supplied with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure concentrations remain accurate throughout the shelf life of the product. Note: Add more solution to the vial than listed. Therefore, accurate volume measurements are necessary to prepare calibration standards. Follow recommended storage and handling conditions to maintain product quality.
    1,2-Dipalmitoyl-rac-glycerol
  • HY-15497
    AZD7687
    1 Publications Verification

    		 Acyltransferase Metabolic Disease
    AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research [1] .
    AZD7687
  • HY-107416
    RHC 80267

    U-57908

    		 DAGL Acyltransferase mAChR COX Phospholipase Neurological Disease Metabolic Disease
    RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC50 of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC50 of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC) [1] .
    RHC 80267
  • HY-108355
    R59949
    1 Publications Verification

    		 PKC Cancer
    R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol [1] .
    R59949
  • HY-131897
    1-Stearoyl-2-arachidonoyl-sn-glycerol
    1 Publications Verification

    		 PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity [1] .
    1-Stearoyl-2-arachidonoyl-sn-glycerol
  • HY-115706
    13-Dilignoceroyl glycerol

    1,3-Ditetracosanoin

    		 Biochemical Assay Reagents Neurological Disease
    13-Dilignoceroyl glycerol is a diacylglycerol containing lignoceric acid (HY-121883 ) at the sn-1 and sn-3 positions. Lignoceric acid is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy research [1] .
    13-Dilignoceroyl glycerol
  • HY-32219
    T863
    Maximum Cited Publications
    13 Publications Verification

    		 Acyltransferase Metabolic Disease
    T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC50 of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells [1] .
    T863
  • HY-107613A
    R 59-022 hydrochloride
    1 Publications Verification

    DKGI-I hydrochloride; diacylglycerol kinase inhibitor I hydrochloride

    		 PKC 5-HT Receptor Infection Inflammation/Immunology Cancer
    R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils [1] .
    R 59-022 hydrochloride
  • HY-107613
    R 59-022
    1 Publications Verification

    DKGI-I; diacylglycerol kinase inhibitor I

    		 PKC 5-HT Receptor Inflammation/Immunology
    R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils [1] .
    R 59-022
  • HY-W699318
    1-Oleoyl-2-palmitoylglycerol

    		Reactive Oxygen Species (ROS) Others
    1-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells [1] .
    1-Oleoyl-2-palmitoylglycerol
  • HY-107613R
    R 59-022 (Standard)

    		PKC 5-HT Receptor Inflammation/Immunology
    R 59-022 (Standard) is the analytical standard of R 59-022. This product is intended for research and analytical applications. R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils [1] .
    R 59-022 (Standard)
  • HY-148123
    Glycerophospholipids, cephalins

    		Biochemical Assay Reagents Neurological Disease
    Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease) [1] .
    Glycerophospholipids, cephalins
  • HY-131897S
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol

    		Isotope-Labeled Compounds PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity [1] .
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
  • HY-N9530
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

    		Acyltransferase Angiotensin Receptor Bacterial Infection Cardiovascular Disease Metabolic Disease
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL [1] .
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

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