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  4. Glycerophospholipids, cephalins

Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease).

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Glycerophospholipids, cephalins Chemical Structure

Glycerophospholipids, cephalins Chemical Structure

CAS No. : 39382-08-6

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Glycerophospholipids, cephalins Related Antibodies

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Description

Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease)[1][2].

In Vitro

Glycerophospholipids, cephalins (50 μM; 24 h) increase the apoptotic rate of rat cortical neurons by activating phospholipase PLA2 and releasing arachidonic acid[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycerophospholipids, cephalins Related Antibodies

Cell Viability Assay[2]

Cell Line: Rat hippocampal neurons
Concentration: 20 μM
Incubation Time: 12 h
Result: Increased phosphorylation of PKC and ERK1/2, indicating activation of the PLC/DAG signaling pathway.
In Vivo

Glycerophospholipids, cephalins (3-month DHA diet; dietary intervention; daily; 3 months) significantly reduces amyloid plaque burden in the cortex and hippocampus and increases drebrin levels in the hippocampus in female APP/PS1 transgenic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg2576 mice (male, weight 18-22g, 6 months old) with Alzheimer’s disease model[1]
Dosage: 100 mg/kg Arachidonic acid (Glycerophospholipids, cephalins metabolism)
Administration: Intraperitoneal injection, once daily, 4 weeks
Result: Induced significant increase in brain F₂-isoprostane levels and promoted Aβ1-42 aggregation, leading to cognitive impairment.
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Glycerophospholipids, cephalins]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

THF : ≥ 100 mg/mL

H2O : 2 mg/mL (ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

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Purity & Documentation

Purity: 88.59%

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COA (241 KB)

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Glycerophospholipids, cephalins Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycerophospholipids, cephalins39382-08-6Biochemical Assay ReagentsInhibitorinhibitorinhibit

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