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α adrenergic Agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (123) 5-HT Receptor (23) Adenosine Receptor (3) Akt (3) AMPK (3) Antibiotic (1) Apoptosis (3) Autophagy (8) Bacterial (1) Calcium Channel (1) Dopamine Receptor (12) Drug Metabolite (2) Endogenous Metabolite (19) Fluorescent Dye (1) Imidazoline Receptor (1) Interleukin Related (5) Isotope-Labeled Compounds (11) LXR (1) MAP3K (1) MDM-2/p53 (1) mGluR (1) Monoamine Oxidase (4) Parasite (4) PKC (1) Reference Standards (7) ROS Kinase (1) Sigma Receptor (2) TNF Receptor (5) VEGFR (5)
By Research Areas:	Cancer (25) Cardiovascular Disease (57) Endocrinology (69) Infection (5) Inflammation/Immunology (13) Metabolic Disease (4) Neurological Disease (53)

By Targets:

Adrenergic Receptor (123)

5-HT Receptor (23)

Adenosine Receptor (3)

Akt (3)

AMPK (3)

Antibiotic (1)

Apoptosis (3)

Autophagy (8)

Bacterial (1)

Calcium Channel (1)

Dopamine Receptor (12)

Drug Metabolite (2)

Endogenous Metabolite (19)

Fluorescent Dye (1)

Imidazoline Receptor (1)

Interleukin Related (5)

Isotope-Labeled Compounds (11)

LXR (1)

MAP3K (1)

MDM-2/p53 (1)

mGluR (1)

Monoamine Oxidase (4)

Parasite (4)

PKC (1)

Reference Standards (7)

ROS Kinase (1)

Sigma Receptor (2)

TNF Receptor (5)

VEGFR (5)

By Research Areas:

Cancer (25)

Cardiovascular Disease (57)

Endocrinology (69)

Infection (5)

Inflammation/Immunology (13)

Metabolic Disease (4)

Neurological Disease (53)

139

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Adrenergic Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0144A

Etilefrine hydrochloride	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-A0144

Etilefrine	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-12721

Clonidine 5 Publications Verification	Adrenergic Receptor	Neurological Disease Cancer
Clonidine is an **alpha 2-adrenergic** agonist .

HY-W702712

3-Hydroxy xylazine	Adrenergic Receptor	Neurological Disease
3-Hydroxy xylazine is a metabolite of the α2-adrenergic receptor agonist Xylazine.

HY-B0659

Brimonidine 3 Publications Verification UK 14304; AGN190342	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-101717

Indanidine	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Indanidine is an *alpha-adrenergic* agonist.

HY-B0659A

Brimonidine tartrate 3 Publications Verification UK 14304 tartrate; AGN190342 tartrate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-A0144AR

Etilefrine hydrochloride (Standard)	Reference Standards AMPK Adrenergic Receptor Akt	Cardiovascular Disease
Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-107358A

Lidamidine hydrochloride WHR-1142A	Adrenergic Receptor	Others
Lidamidine hydrochloride (WHR-1142A) is an *α2-adrenergic* receptor agonist and antidiarrheal agent .

HY-B0194A

Tizanidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

HY-W014726

DL-Phenylephrine hydrochloride (±)-Phenylephrine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.

HY-B0194

Tizanidine	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

HY-B0459

Scopine 6,7-Epoxytropine	Adrenergic Receptor	Neurological Disease Endocrinology
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

HY-107358

Lidamidine WHR-1142A free base	Adrenergic Receptor	Metabolic Disease
Lidamidine (WHR-1142A free base) is an *α2-adrenergic* receptor agonist and antidiarrheal agent .

HY-U00371

AR-08	Adrenergic Receptor	Neurological Disease Endocrinology
AR-08 is an agonist of *α2-adrenergic* receptor**, used for the treatment of attention deficit hyperactivety disorder (ADHD).

HY-B1696

Methyldopate	Adrenergic Receptor	Cardiovascular Disease
Methyldopate is an ethyl ester proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research .

HY-B1696A

Methyldopate hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Methyldopate hydrochloride is an ethyl ester hydrochloride proagent of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate hydrochloride has the potential for severe hypertension research .

HY-12721S

Clonidine-d4 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease
Clonidine-d₄ (hydrochloride) is the deuterium labeled Clonidine. Clonidine hydrochloride is an alpha 2-adrenergic agonist .

HY-B0163

Detomidine	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine, an imidazole derivative, is a potent *α2-adrenergic* agonist. Detomidine produces dose-dependent analgesic effects .

HY-B0163A

Detomidine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine hydrochloride, an imidazole derivative, is a potent *α2-adrenergic* agonist. Detomidine hydrochloride produces dose-dependent analgesic effects .

HY-B0659S

Brimonidine-d4	Adrenergic Receptor	Endocrinology
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0225AS

Methyldopa-d3 hydrochloride L-(-)-α-Methyldopa-d₃ hydrochloride; MK-351-d₃ hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0459A

Scopine hydrochloride 6,7-Epoxytropine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Scopine hydrochloride (6,7-Epoxytropine hydrochloride) is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

HY-129697

3-Hydroxy Medetomidine 3-OH Medetomidine; Medetomidine metabolite MIII	Drug Metabolite	Metabolic Disease
3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.

HY-167925

Rec 15/2615	Adrenergic Receptor Calcium Channel	Endocrinology
Rec 15/2615 is a potent α(1)-adrenergic agonist that stimulates small cholangiocyte proliferation through the activation of calcium-dependent signaling pathways.

HY-172026

N-Nitroso clonidine	Adrenergic Receptor	Neurological Disease
N-Nitroso clonidine, a nitrosamine, is a metabolite of Clonidine (HY-12721). Clonidine is an alpha 2-adrenergic agonist .

HY-B0225BR

Methyldopa hydrate (Standard)	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-12721R

Clonidine (Standard)	Adrenergic Receptor	Neurological Disease Cancer
Clonidine (Standard) is the analytical standard of Clonidine. This product is intended for research and analytical applications. Clonidine is an **alpha 2-adrenergic** agonist .

HY-B0659R

Brimonidine (Standard)	Adrenergic Receptor	Endocrinology Cancer
Brimonidine (Standard) is the analytical standard of Brimonidine. This product is intended for research and analytical applications. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-112074

Tiamenidine HOE 440	Adrenergic Receptor	Cardiovascular Disease
Tiamenidine (HOE 440) is an orally active *α2-adrenergic* receptor** agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research .

HY-162620

α2A-AR agonist 1	Adrenergic Receptor	Cancer
α2A-AR agonist 1 (Compound B9) is a selective agonist for *α2-adrenergic* receptor** (α2A-AR) with EC₅₀ of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED₅₀ of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes .

HY-112658

p-Iodoclonidine hydrochloride	Adrenergic Receptor Adenosine Receptor	Endocrinology
p-Iodoclonidine hydrochloride is a partial agonist of *α2-adrenergic* receptor*. p-Iodoclonidine hydrochloride also has minimal agonist* activity in inhibiting adenylate cyclase in platelet membranes, and potentiates ADP induced platelet aggregation with an EC₅₀ of 1.5 μM .

HY-19057

Vatinoxan MK-467; L-659066	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Vatinoxan (MK-467) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia .

HY-B0566

Guanabenz Acetate 2 Publications Verification BR-750; Wy8678 acetate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.

HY-135895

Detomidine carboxylic acid	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic *α2-adrenergic* agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action .

HY-B0194S

Tizanidine-d4	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons .

HY-B0659AR

Brimonidine (tartrate) (Standard)	Adrenergic Receptor	Endocrinology Cancer
Brimonidine (tartrate) (Standard) is the analytical standard of Brimonidine (tartrate). This product is intended for research and analytical applications. Brimonidine tartrate (UK 14304 tartrate) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B1116

Metaraminol tartrate Metaradrine tartrate	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Metaraminol tartrate?(Metaradrine tartrate) is an *α-adrenergic* agonist . Metaraminol tartrate is a sympathomimetic amine that directly and indirectly affects adrenergic receptors, with alpha effects being predominant.Metaraminol tartrate acts as a vasopressor agent .

HY-17034BS

Medetomidine-d3 hydrochloride MPV785-d₃	Isotope-Labeled Compounds Adrenergic Receptor	Neurological Disease Endocrinology
Medetomidine-d₃ (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor .

HY-B0163AR

Detomidine (hydrochloride) (Standard)	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine (hydrochloride) (Standard) is the analytical standard of Detomidine (hydrochloride). This product is intended for research and analytical applications. Detomidine hydrochloride, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine hydrochloride produces dose-dependent analgesic effects .

HY-N0132A

Synephrine hydrochloride Oxedrine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Synephrine (Oxedrine) hydrochloride, an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss .

HY-N0132

Synephrine Oxedrine	Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Synephrine (Oxedrine), an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine is a sympathomimetic compound and can be used for weight loss .

HY-U00123

Guanoxabenz Hydroxyguanabenz	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Guanoxabenz is an *α2 adrenergic* receptor** agonist, with a K_i of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor .

HY-119456

Romifidine	Adrenergic Receptor	Neurological Disease
Romifidine is an *α₂ adrenergic* receptor** agonist. Romifidine shows sedation effects in vivo .

HY-119456A

Romifidine hydrochloride	Adrenergic Receptor	Neurological Disease
Romifidine hydrochloride is an *α₂ adrenergic* receptor** agonist. Romifidine hydrochloride shows sedation effects in vivo .

HY-117158

SKF 89748	Adrenergic Receptor	Others
SKF 89748 is an α1-adrenergic receptor agonist with the activity of inhibiting food and water intake. SKF 89748 inhibits food and water intake in adult male rats with an ED50 of 0.37mg/kg for inhibiting food intake.

HY-U00123A

Guanoxabenz hydrochloride Hydroxyguanabenz hydrochloride	Adrenergic Receptor	Neurological Disease
Guanoxabenz (Hydroxyguanabenz) hydrochloride is an *α2 adrenergic* receptor** agonist, with a K_i of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor .

Cat. No.	Product Name	Type

HY-A0144A

Etilefrine hydrochloride

Biochemical Assay Reagents

Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

HY-A0144AR

Etilefrine hydrochloride (Standard)

Biochemical Assay Reagents

Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0225B

Methyldopa hydrate 2 Publications Verification L-(-)-α-Methyldopa hydrate; MK-351 hydrate	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0225

Methyldopa 2 Publications Verification L-(-)-α-Methyldopa; MK-351	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Hippocastanaceae Source classification Aesculus hippocastanum Plants Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0459

Scopine 6,7-Epoxytropine	Alkaloids Classification of Application Fields Neurological Disease Datura stramonium L. Source classification Plants Solanaceae Disease Research Fields Endocrinology	Adrenergic Receptor
Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

HY-N0132A

Synephrine hydrochloride Oxedrine hydrochloride	Structural Classification Citrus × aurantium Linnaeus Neurological Disease Classification of Application Fields Source classification Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Phenols Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Synephrine (Oxedrine) hydrochloride, an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss .

HY-N0132

Synephrine Oxedrine	Structural Classification Citrus × aurantium Linnaeus Neurological Disease Classification of Application Fields Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Phenols Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Synephrine (Oxedrine), an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine is a sympathomimetic compound and can be used for weight loss .

HY-A0066A

Tolazoline hydrochloride Imidaline hydrochloride; NSC35110 hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Source classification Alpinia officinarum Hance Plants Disease Research Fields Endocrinology Zingiberaceae	Adrenergic Receptor
Tolazoline hydrochloride (Imidaline hydrochloride) is an *α-adrenergic* receptor** antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-B0225A

Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for *α2-adrenergic* receptors**). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-B0163

Detomidine	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Detomidine, an imidazole derivative, is a potent *α2-adrenergic* agonist. Detomidine produces dose-dependent analgesic effects .

HY-B0225BR

Methyldopa hydrate (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Phenols Polyphenols Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Methyldopa (hydrate) (Standard) is the analytical standard of Methyldopa (hydrate). This product is intended for research and analytical applications. Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-N0132B

Synephrine hemitartrate Oxedrine hemitartrate	Alkaloids Monophenols Source classification Rutaceae Phenols Plants Citrus reticulata Blanco	Adrenergic Receptor Endogenous Metabolite
Synephrine (Oxedrine) hemitartrate, an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine hemitartrate is a sympathomimetic compound and can be used for weight loss .

HY-122440

Scopoline	Source classification Plants	Drug Metabolite Adrenergic Receptor
Scopoline (compound 3a) is a compound formed from Scopine (HY-B0459), an *α1 adrenergic* receptor** agonist .

HY-13715

Norepinephrine Maximum Cited Publications 38 Publications Verification Levarterenol; L-Noradrenaline	Cardiovascular Disease Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715A

Norepinephrine hydrochloride Maximum Cited Publications 38 Publications Verification Levarterenol hydrochloride; L-Noradrenaline hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Mimosa pudica Linn. Leguminosae Other Alkaloids Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715B

Norepinephrine bitartrate monohydrate Maximum Cited Publications 38 Publications Verification Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate	Structural Classification Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-13715C

Norepinephrine tartrate Maximum Cited Publications 38 Publications Verification Levarterenol tartrate; L-Noradrenaline tartrate	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α₁, α₂, β₁ receptors .

HY-N0132R

Synephrine (Standard) Oxedrine (Standard)	Structural Classification Citrus × aurantium Linnaeus Neurological Disease Classification of Application Fields Source classification Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Phenols Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Synephrine (Standard) is the analytical standard of Synephrine. This product is intended for research and analytical applications. Synephrine (Oxedrine), an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine is a sympathomimetic compound and can be used for weight loss .

HY-N0132AR

Synephrine (hydrochloride) (Standard)	Alkaloids Structural Classification Citrus × aurantium Linnaeus Monophenols Other Alkaloids Source classification Rutaceae Phenols Plants Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Synephrine (hydrochloride) (Standard) is the analytical standard of Synephrine (hydrochloride). This product is intended for research and analytical applications. Synephrine (Oxedrine) hydrochloride, an alkaloid, is an *α-adrenergic* and *β-adrenergic* agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss .

HY-A0066AR

Tolazoline hydrochloride (Standard) Imidaline hydrochloride (Standard); NSC35110 hydrochloride (Standard)	Alkaloids Other Alkaloids Source classification Alpinia officinarum Hance Plants Zingiberaceae	Adrenergic Receptor
Tolazoline (hydrochloride) (Standard) is the analytical standard of Tolazoline hydrochloride (HY-A0066A). This product is intended for research and analytical applications. Tolazoline hydrochloride (Imidaline hydrochloride) is an *α-adrenergic* receptor** antagonist. Tolazoline hydrochloride inhibits Noradrenaline (HY-13715)-induced cell contraction, modulates vascular resistance, increases arterial pressure, and reverses bradycardia and tachypnea. Tolazoline hydrochloride can be used to study erectile dysfunction, α₂-adrenergic receptor agonist-related poisoning, and skin vascular disease research .

HY-13715R

Norepinephrine (Standard) Levarterenol (Standard); L-Noradrenaline (Standard)	Structural Classification Phenols Polyphenols Endogenous metabolite	Endogenous Metabolite Adrenergic Receptor Autophagy
Norepinephrine (Standard) is the analytical standard of Norepinephrine. This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors .

HY-131150R

Ristomycin (sulfate) (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Antibiotic
Norfenefrine (hydrochloride) (Standard) is the analytical standard of Norfenefrine (hydrochloride). This product is intended for research and analytical applications. Norfenefrine hydrochloride is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence .

HY-13715AR

Norepinephrine hydrochloride (Standard) Levarterenol hydrochloride (Standard); L-Noradrenaline hydrochloride (Standard)	Alkaloids Mimosa pudica Linn. Leguminosae Other Alkaloids Source classification Phenols Polyphenols Plants	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (hydrochloride) (Standard) is the analytical standard of Norepinephrine (hydrochloride). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].

HY-13715BR

Norepinephrine bitartrate monohydrate (Standard)	Structural Classification Source classification Phenols Endogenous metabolite	Adrenergic Receptor Autophagy Endogenous Metabolite
Norepinephrine (bitartrate monohydrate) (Standard) is the analytical standard of Norepinephrine (bitartrate monohydrate). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .

HY-113352R

7-Methylguanine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Etilefrine (hydrochloride) (Standard) is the analytical standard of Etilefrine (hydrochloride). This product is intended for research and analytical applications. Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension .

HY-W015546R

β-N-methylamino-L-alanine (hydrochloride) (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial mGluR PKC
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-N2037

Higenamine 3 Publications Verification Norcoclaurine; Demethyl-Coclaurine	Alkaloids Structural Classification Classification of Application Fields Ranunculaceae Source classification Phenols Polyphenols Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids Disease Research Fields Endocrinology	MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis
Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a *α1-adrenergic* receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis** and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0194S

Tizanidine-d4
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons .

HY-B0556AS

Tetrahydrozoline-d4 hydrochloride
Tetrahydrozoline-d₄ (hydrochloride) is the deuterium labeled Tetrahydrozoline hydrochloride. Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion .

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride

(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12721S

Clonidine-d4 hydrochloride
Clonidine-d₄ (hydrochloride) is the deuterium labeled Clonidine. Clonidine hydrochloride is an alpha 2-adrenergic agonist .

HY-B0659S

Brimonidine-d4
Brimonidine-d₄ is the deuterium labeled Brimonidine. Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

HY-B0225AS

Methyldopa-d3 hydrochloride
Methyldopa-d₃ (hydrochloride) is deuterium labeled Methyldopa (hydrochloride). Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .

HY-17034BS

Medetomidine-d3 hydrochloride
Medetomidine-d₃ (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor .

HY-13715S

(Rac)-Norepinephrine-d3 formate
(Rac)-Norepinephrine-d₃ (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .

HY-B1111S1

Amitraz-d3
Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-B1111S

Amitraz-d6
Amitraz-d6 (BTS-27419-d6) is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-B0475S

Xylometazoline-d4 hydrochloride
Xylometazoline-d₄ hydrochloride is deuterated labeled Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride is an *α-adrenergic* receptor** agonist (K_i=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

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