PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi)

Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

Ptk7 Protein is an inactive tyrosine kinase that plays a crucial role in the Wnt signaling pathway, specifically in both the non-canonical (Wnt/planar cell polarity signaling) and canonical Wnt signaling pathways. It is involved in various cellular processes, including cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. Ptk7 Protein also contributes to embryogenesis, epithelial tissue organization, and angiogenesis. Additionally, it interacts with CTNNB1, further highlighting its significance in Wnt signaling.

Mouse

HEK293

C-Avi;C-8*His

Q8BKG3 (A23-T696)

71461

Extracellular Domain

Approximately 90-110 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.