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  3. PICK1 Protein, Human (Biotinylated, Avi)

PICK1 Protein, Human (Biotinylated, Avi) is the recombinant human-derived PICK1, expressed by E. coli , with Avi labeled tag. ,

For research use only. We do not sell to patients.

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Description

PICK1 Protein, Human (Biotinylated, Avi) is the recombinant human-derived PICK1, expressed by E. coli , with Avi labeled tag. ,

Background

PICK1 is a probable adapter protein that binds to and organizes the subcellular localization of various membrane proteins containing PDZ recognition sequences. It is involved in the clustering of multiple receptors, potentially by acting at the receptor internalization level. PICK1 plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors and may be regulated upon PRKCA activation. Additionally, PICK1 may modulate ASIC1/ASIC3 channels and regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex, a function competitive with nucleation promoting factors and linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Through interaction with the Arp2/3 complex, PICK1 is involved in regulating synaptic plasticity at excitatory synapses and is required for spine shrinkage during long-term depression (LTD). PICK1 also regulates astrocyte morphology, antagonizing the function of the Arp2/3 complex activator WASL/N-WASP.

Species

Human

Source

E. coli

Tag

Avi

Accession

Q9NRD5-1 (F2-S415)

Gene ID

9463

Protein Length

Partial

Synonyms
PRKCABP
Predicted Molecular Mass
48.6 kDa
Purity

Greater than 85% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

PICK1 Protein, Human (Biotinylated, Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
PICK1 Protein, Human (Biotinylated, Avi)
Cat. No.:
HY-P703269
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