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  4. PDCD6IP Protein, Human (His, Strep)

PDCD6IP Protein, Human (His, Strep) is the recombinant human-derived PDCD6IP, expressed by E. coli , with Strep, His labeled tag. ,

For research use only. We do not sell to patients.

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Description

PDCD6IP Protein, Human (His, Strep) is the recombinant human-derived PDCD6IP, expressed by E. coli , with Strep, His labeled tag. ,
Background

ALIX is a multifunctional protein involved in endocytosis, multivesicular body (MVB) biogenesis, membrane repair, cytokinesis, apoptosis, and tight junction maintenance. As a Class E VPS protein, it facilitates cargo sorting into intralumenal vesicles (ILVs) within MVBs by interacting with ESCRT complexes (ESCRT-O, -I, -II, -III) and binding lysobisphosphatidic acid (LBPA). It acts as an adapter for ESCRT-III proteins (e.g., CHMP4) and is essential for cytokinesis completion. ALIX regulates exosome biogenesis with SDC1/4 and SDCBP and may modulate apoptosis and cell proliferation. By interacting with F-actin, PARD3, and TJP1, it ensures proper actomyosin-tight junction assembly in epithelial polarity (By similarity). Additionally, ALIX supports HIV-1 budding by functionally replacing TSG101 via CHMP4B interaction, highlighting its role in viral release and topologically similar membrane fission events.
Species

Human
Source

E. coli
Tag

Strep;His
Accession

Q8WUM4-1 (M1-R698)
Gene ID

10015
Protein Length

Partial
Synonyms
AIP1; ALIX; KIAA1375
Predicted Molecular Mass
81 kDa
Purity

Greater than 80% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

PDCD6IP Protein, Human (His, Strep) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PDCD6IP Protein, Human (His, Strep)
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