OX40/TNFRSF4 Protein, Human (HEK293, mFc)

OX40/TNFRSF4, a receptor for TNFSF4/OX40L/GP34, crucially acts as a costimulatory molecule in long-term T-cell immunity. Additionally, OX40 functions as a receptor for human herpesvirus 6B/HHV-6B during microbial infections, highlighting its dual role in the adaptive immune response and potential involvement in specific viral interactions. OX40/TNFRSF4 Protein, Human (HEK293, mFc) is the recombinant human-derived OX40/TNFRSF4 protein, expressed by HEK293, with C-mFc labeled tag.

OX40, also known as TNFRSF4, functions as a receptor for TNFSF4/OX40L/GP34 and serves as a crucial costimulatory molecule implicated in long-term T-cell immunity. Beyond its role in immune regulation, OX40 also acts as a receptor for human herpesvirus 6B/HHV-6B during microbial infections. This dual functionality underscores OX40's significance in both the adaptive immune response and its potential involvement in specific viral interactions.

Human

HEK293

C-mFc

P43489 (L29-A216)

7293

Partial

Approximately 58-66 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.