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  3. NKp46/NCR1 Protein, Cynomolgus (HEK293, Llama Fc)

NKp46/NCR1 Protein, Cynomolgus (HEK293, Llama Fc)

Cat. No.: HY-P704823
Handling Instructions Technical Support

NKp46/NCR1 Protein, a pivotal cytotoxicity-activating receptor, enhances the efficiency of activated natural killer (NK) cells in destroying tumor cells. It interacts with CD3Z and FCER1G, potentially amplifying NK cell recognition and targeted lysis of cancerous cells. NKp46/NCR1 Protein, Cynomolgus (HEK293, Llama Fc) is the recombinant cynomolgus-derived NKp46/NCR1 protein, expressed by HEK293, with C-Llama Fc labeled tag.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
100 μg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
> 100 μg   Get quote  
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  • Biological Activity

  • Technical Parameters

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  • Documentation

Description

NKp46/NCR1 Protein, a pivotal cytotoxicity-activating receptor, enhances the efficiency of activated natural killer (NK) cells in destroying tumor cells. It interacts with CD3Z and FCER1G, potentially amplifying NK cell recognition and targeted lysis of cancerous cells. NKp46/NCR1 Protein, Cynomolgus (HEK293, Llama Fc) is the recombinant cynomolgus-derived NKp46/NCR1 protein, expressed by HEK293, with C-Llama Fc labeled tag.

Background

NKp46/NCR1 Protein is a cell receptor that plays a crucial role in enhancing the efficiency of activated natural killer (NK) cells in destroying tumor cells. It acts as a cytotoxicity-activating receptor, potentially aiding in the process of tumor cell lysis by NK cells. NKp46/NCR1 Protein interacts with CD3Z and FCER1G, which may further enhance the ability of NK cells to recognize and target cancerous cells.

Species

Cynomolgus

Source

HEK293

Tag

C-Llama Fc

Accession

Q95JB9 (P22-R257)

Gene ID

102115479

Molecular Construction
N-term
NKp46 (P22-R257)
Accession # Q95JB9
Llama Fc
C-term
Synonyms
CD335; Ly94; NCR1; NKp46; MAR-1; NKP46FLJ99094
Predicted Molecular Mass
54.7 kDa.
Molecular Weight

Approximately 60-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Glycosylation
Yes
Purity

Greater than 90% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from 0.22 μm filtered solution of 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

NKp46/NCR1 Protein, Cynomolgus (HEK293, Llama Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
NKp46/NCR1 Protein, Cynomolgus (HEK293, Llama Fc)
Cat. No.:
HY-P704823
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