LRP-1 Cluster IV Protein, Human (CHO, His)

LRP-1 Cluster II protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster II protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster IV Protein, Human (CHO, His) is the recombinant human-derived LRP-1 Cluster IV protein, expressed by CHO , with C-10*His labeled tag.

LRP-1 Cluster II Protein emerges as a multifunctional endocytic receptor, playing pivotal roles in both endocytosis and the phagocytosis of apoptotic cells. Its significance extends to essential functions in early embryonic development and cellular lipid homeostasis. Additionally, LRP-1 Cluster II is actively involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the localized metabolism of complexes formed between plasminogen activators and their endogenous inhibitors. Acting as an LRPAP1 alpha-2-macroglobulin receptor, it further participates in various cellular events, including the endocytosis and subsequent spread of TAU/MAPT. Moreover, LRP-1 Cluster II may modulate critical cellular processes such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling, and neurotransmission. Notably, in microbial infection, the protein functions as a receptor for Pseudomonas aeruginosa exotoxin A, highlighting its diverse and intricate roles in cellular physiology and host-pathogen interactions.

Human

CHO

C-10*His

Q07954-1 (S3332-D3779)

4035

Partial

Approximately 60-88 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.