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  4. CLC1 Protein, Human (HEK293)

CLC1 Protein, Human (HEK293) is the recombinant human-derived CLC1, expressed by HEK293 , with tag Free labeled tag.

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

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Description

CLC1 Protein, Human (HEK293) is the recombinant human-derived CLC1, expressed by HEK293 , with tag Free labeled tag.
Background

CLC1 is a voltage-gated chloride channel that plays a key role in skeletal muscle excitability. It generates the majority of plasma membrane chloride conductance in skeletal muscle fibers, stabilizing the resting membrane potential and contributing to the repolarization phase during action potential firing. The channel forms a homodimer with each subunit possessing its own ion conduction pathway, producing double-barreled currents regulated by two types of gates: fast glutamate gates controlling each subunit independently and a slow common gate operating both subunits simultaneously. CLC1 exhibits significant open probability at resting membrane potential and is further activated upon depolarization. It shows ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide.
Species

Human
Source

HEK293
Tag

Tag Free
Accession

P35523 (K81-L988)
Gene ID

1180
Protein Length

Partial
Synonyms
CLC1
Predicted Molecular Mass
100.1 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CLC1 Protein, Human (HEK293) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CLC1 Protein, Human (HEK293)
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