CD6 Protein, Human (HEK293, His)

The CD6 protein is located on the outer membrane of T lymphocytes and other immune cells. It has three cysteine-rich scavenger receptor (SRCR) domains and a binding site for activated leukocyte cell adhesion molecules. CD6 Protein, Human (HEK293, His) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-His labeled tag.

The CD6 protein is situated on the outer membrane of T-lymphocytes and various other immune cells. Featuring three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule, this protein plays a crucial role in sustaining T cell activation. Additionally, there is evidence suggesting an association between this gene and susceptibility to multiple sclerosis. Multiple transcript variants, encoding diverse isoforms, have been identified for this gene, with biased expression observed in lymph node, appendix, and nine other tissues.

Immobilized Human CD6, His Tag at 1 or 2 μg/mL (100 μL/well) on the plate. Dose response curve for Human ALCAM, hFc Tag with the EC₅₀ of ≤6.3 ng/mL determined by ELISA.

Human

HEK293

C-8*His

NP_006716.3 (H18-L402)

923  [NCBI]

Partial

Approximately 70-90 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.