Cadherin-13 Protein, Mouse (HEK293, Fc)

Cadherin-13 proteins are calcium-dependent cell adhesion molecules that exhibit a preference for homogeneous interactions, promote connections between adjacent cells, and may play a role in cell type sorting. Cadherin-13 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Cadherin-13 protein, expressed by HEK293 , with C-hFc labeled tag.

Cadherin-13, a calcium-dependent cell adhesion protein, stands out for its unique features in comparison to classical cadherins. Unlike the typical cadherin EC1 domain strand-swapping mechanism for homodimerization, Cadherin-13 achieves this through a distinct homophilic adhesive interface, connecting two elongated EC1-EC2 domains near their Ca2+-binding sites. This arrangement forms a tetrahedral, X-like shape, showcasing a different mode of homodimerization. This protein is implicated in potentially acting as a negative regulator of neural cell growth, and its ability to preferentially interact with itself in a homophilic manner suggests a role in contributing to the sorting of heterogeneous cell types within neural tissues.

Mouse

HEK293

C-hFc

Q9WTR5 (M1-A692)

12554  [NCBI]

Approximately 100.6 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.