ABCA2 Protein, Human (HEK293, His, Strep, Flag)

ABCA2 Protein, Human (HEK293, His, Strep, Flag) is the recombinant human-derived ABCA2, expressed by HEK293, with Strep, His, Flag labeled tag.

ABCA2 is a probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating intracellular sphingolipid metabolism, thereby participating in cholesterol homeostasis. It may alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet, which increases acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine and leading to the sequestration of free cholesterol in lysosomes. Additionally, ABCA2 regulates amyloid-beta production either by activating a signaling pathway that modulates amyloid precursor protein transcription through sphingolipid metabolism or via its role in gamma-secretase processing of APP. It may also play a role in myelin formation (By similarity).

Human

HEK293

N-His;C-Flag;N-StrepⅡ

Q9BZC7-1 (G2-C2435)

20

Partial

Greater than 85% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.04% (w/v) GDN, 0.0002% (w/v) CHS,cOmplete Protease Inhibitor Tablet.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.