2. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. PI3K Epigenetic Reader Domain DNA/RNA Synthesis Akt c-Myc AMPK
  4. PI3Kα-IN-28

PI3Kα-IN-28 is an efficient dual targeted PI3K/BRD4 inhibitor. PI3Kα-IN-28 can inhibit the proliferation of various cells, such as KYSE180 (IC50 = 1.46 µM) and KYSE450 (IC50 = 0.57 µM) cells. PI3Kα-IN-28 can concentration dependently inhibit migration and colony formation, induce G0/G1 phase arrest, significantly inhibit DNA synthesis, and significantly increase the proportion of senescent cells. PI3Kα-IN-28 can inhibit the expression of p-AKT and c-Myc and activate the AMPK-p27 pathway. PI3Kα-IN-28 can be used for research on cancers such as esophageal cancer.

For research use only. We do not sell to patients.

PI3Kα-IN-28

PI3Kα-IN-28 Chemical Structure

CAS No. : 3095278-75-1

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PI3Kα-IN-28 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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Description

PI3Kα-IN-28 is an efficient dual targeted PI3K/BRD4 inhibitor. PI3Kα-IN-28 can inhibit the proliferation of various cells, such as KYSE180 (IC50 = 1.46 µM) and KYSE450 (IC50 = 0.57 µM) cells. PI3Kα-IN-28 can concentration dependently inhibit migration and colony formation, induce G0/G1 phase arrest, significantly inhibit DNA synthesis, and significantly increase the proportion of senescent cells. PI3Kα-IN-28 can inhibit the expression of p-AKT and c-Myc and activate the AMPK-p27 pathway. PI3Kα-IN-28 can be used for research on cancers such as esophageal cancer[1].

IC50 & Target[1]

PI3Kα

 

BRD4

 

Molecular Weight

1021.59

Formula

C51H51ClF2N10O5S2
CAS No.
SMILES

CC1=C2C(C(OC3CCN(CC3)CC4CCN(CC4)C(C[C@@H]5N=C(C6=C(N7C5=NN=C7C)SC(C)=C6C)C8=CC=C(C=C8)Cl)=O)=CC(C9=CC(NS(C%10=CC=C(C=C%10F)F)(=O)=O)=C(N=C9)OC)=C2)=NC=N1
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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PI3Kα-IN-28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-283095278-75-1PI3KEpigenetic Reader DomainDNA/RNA SynthesisAktc-MycAMPKPhosphoinositide 3-kinasePKBProtein kinase BMycAMP-activated protein kinaseBRD4DNA synthesisAKTesophagealcancerInhibitorinhibitorinhibit

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