2. NF-κB
  3. NF-κB
  4. NF-κB degrader 1

NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases.

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NF-κB degrader 1 Chemical Structure

NF-κB degrader 1 Chemical Structure

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NF-κB degrader 1 Related Antibodies

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Description

NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases[1].

IC50 & Target

p50

 

Molecular Weight

328.36

Formula

C19H20O5
SMILES

O=C1OC2=C(C=CC=C2C=C1)C(/C(OC(CC(C)C)=O)=C(C)\C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NF-κB degrader 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB degrader 1NF-κBNuclear factor-κBNuclear factor-kappaBNF-κB1TNF-αNOinflammation-related diseasesInhibitorinhibitorinhibit

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