2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. MK-8666

MK-8666 is a potent and selective partial GPR40 agonist (EC50 = 0.54 nM for human GPR40). MK-8666 shows selectivity over GPR119, GPR43, GPR41, GPR120, and other G-protein-coupled receptors (GPCRs). MK-8666 reduces glucose in the rodent. MK-8666 can be used for type 2 diabetes research[1][2].

For research use only. We do not sell to patients.

MK-8666

MK-8666 Chemical Structure

CAS No. : 1544739-75-4

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Other Forms of MK-8666:

MK-8666 Related Antibodies

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Description

MK-8666 is a potent and selective partial GPR40 agonist (EC50 = 0.54 nM for human GPR40). MK-8666 shows selectivity over GPR119, GPR43, GPR41, GPR120, and other G-protein-coupled receptors (GPCRs). MK-8666 reduces glucose in the rodent. MK-8666 can be used for type 2 diabetes research[1][2].

IC50 & Target[2]

GPR40

0.54 nM (EC50)

Molecular Weight

521.62

Formula

C29H31NO6S
CAS No.
SMILES

O=C(O)[C@H]1[C@]([H])(CC2=C3C=NC(OCC4=CC(C5=C(C=C(C=C5C)OCCCS(=O)(C)=O)C)=CC=C4)=C2)[C@@]13[H]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MK-8666 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-86661544739-75-4MK8666MK 8666Free Fatty Acid ReceptorFFARGPR40GPCRsrodenttype 2 diabetespartial agonistInhibitorinhibitorinhibit

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