2. Academic Validation
  3. Ceria nanoparticles alleviate myocardial ischemia-reperfusion injury by inhibiting cardiomyocyte apoptosis via alleviating ROS mediated excessive mitochondrial fission

Ceria nanoparticles alleviate myocardial ischemia-reperfusion injury by inhibiting cardiomyocyte apoptosis via alleviating ROS mediated excessive mitochondrial fission

  • Mater Today Bio. 2025 Apr 17:32:101770. doi: 10.1016/j.mtbio.2025.101770.
Ying Sun 1 2 3,  Jiabao Xu 1 3,  Ling Zou 3,  Yan Tan 1 4 5,  Jie Li 2 6,  Haoran Xin 2 6,  Yanli Guo 7,  Weikai Kong 8,  Dingyuan Tian 2 6,  Xinyu Bao 1 2 6,  Xiaoqin Wan 1 2 6,  Xiaoxu Li 4 5,  Zhihui Zhang 2 6,  Xiaochao Yang 3,  Fang Deng 1 4 5
Affiliations

Affiliations

  • 1 Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing, 400038, China.
  • 2 Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
  • 3 School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, 400038, China.
  • 4 Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China.
  • 5 Key Laboratory of High Altitude Medicine, PLA, Chongqing, 400038, China.
  • 6 Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease, Ministry of Education of China, Chongqing, 400038, China.
  • 7 Department of Ultrasound, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
  • 8 Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Army Medical University, Chongqing, 400038, China.
PMID: 40290893 DOI: 10.1016/j.mtbio.2025.101770
Abstract

Reperfusion through thrombolytic therapy or primary percutaneous coronary intervention is commonly used to deal with acute myocardial infarction. However, the reperfusion procedure is accompanied by myocardial ischemia-reperfusion injury (MIRI). Currently, there is no therapeutics that can effectively deal with MIRI in clinical practice. Herein, the potential of ceria nanoparticles (CNPs) coated by different ligands in the treatment of rat MIRI is evaluated. The results demonstrate that CNPs can effectively modulate the oxidative stress in the heart tissue through the elimination of Reactive Oxygen Species (ROS) and stimulation of endogenous antioxidant system. The inhibition of oxidative stress results in the reduction of p-Drp1 (Ser 616) which is critical in driving the fission and fragmentation of mitochondria. The improved mitochondrial dynamics saves the cardiomyocytes from Apoptosis and reduces the acute injury of left ventricular wall during the MIRI. The ejection function of the left ventricle for both the short-term and long-term MIRI rats is well preserved. We therefore believe based on these results that the administration of CNPs is beneficial in the attenuation of MIRI during the acute stage. These findings provide useful information for the future fabrication of inorganic antioxidant nanomedicine for the treatment of MIRI.

Keywords

Ceria nanoparticles; Mitochondria; Myocardial ischemia-reperfusion injury; Oxidative stress; Reactive oxygen species.

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