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  5. Hexadecanamide

Hexadecanamide  (Synonyms: Palmitamide)

Cat. No.: HY-121389 Purity: ≥97.0%
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Hexadecanamide (Palmitamide) is a fatty acid amide that has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide exerts protective effects in Staphylococcus aureus- and SARA-induced mastitis. Hexadecanamide suppresses S. aureus-induced activation of the NF-κB pathway and improves blood-milk barrier integrity. Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro. Hexadecanamide can be studied in research for mastitis and asthenozoospermia.

For research use only. We do not sell to patients.

Hexadecanamide Chemical Structure

Hexadecanamide Chemical Structure

CAS No. : 629-54-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Hexadecanamide:

Hexadecanamide Related Antibodies

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Description

Hexadecanamide (Palmitamide) is a fatty acid amide that has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide exerts protective effects in Staphylococcus aureus- and SARA-induced mastitis. Hexadecanamide suppresses S. aureus-induced activation of the NF-κB pathway and improves blood-milk barrier integrity. Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro. Hexadecanamide can be studied in research for mastitis and asthenozoospermia[1][2].

IC50 & Target

PPARα

 

In Vitro

Hexadecanamide (Compound HEX) (5 μM, 2 h) limits the activation of mammary NF-κB via activating the PPARα-SIRT1 axis in MMECs[1].
Hexadecanamide (10 nM, 0-72 h) exerts a significant enhancing effect on sperm motility[2].
Hexadecanamide (0-1.5 nM, 72 h) results in a significant increase in the protein levels of both PAOX and CA2 in sperm cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hexadecanamide Related Antibodies
In Vivo

Hexadecanamide (Compound HEX) (1.25-5 mg/kg. p.o., 15 d) reduces mammary S. aureus loads and attenuates mammary damage in a dose-dependent manner in S. aureus infected mice[1].
Hexadecanamide (5 mg/kg, p.o., 10 d) effectively reduces colonic inflammation in SARA mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: S. aureus infected male and female BALB/c mice (21-25 g, 6-8 w)[1]
Dosage: 1.25, 2.5, 5 mg/kg
Administration: Oral gavage (p.o.), 15 d
Result: Reduced inflammatory cell infiltration and structure destruction.
Decreased inflammatory markers (MPO activity, TNF-α, IL-1β) dose-dependently.
Reversed the decrease in the TJs proteins, ZO-1, Occludin, and Claudin-3 caused by S. aureus.
Repaired the blood-milk barrier injury induced by S. aureus.
Animal Model: BALB/c mice model with S-RMT-induced mucosal barrier injury[1]
Dosage: 5 mg/kg
Administration: Oral gavage (p.o.), 10 d
Result: Increased mucin-2 expression and improved S-RMT-induced mucosal barrier injury in S-RMT mice.
Distinctly mitigated the upregulation of inflammatory markers caused by S-RMT.
Reversed the SARA aggravated S. aureus-induced mastitis.
Molecular Weight

255.44

Formula

C16H33NO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(CCCCCCCCCCCCCCC)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (19.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9148 mL 19.5741 mL 39.1481 mL
5 mM 0.7830 mL 3.9148 mL 7.8296 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (238 KB) HNMR (245 KB) MS (81 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9148 mL 19.5741 mL 39.1481 mL 97.8703 mL
5 mM 0.7830 mL 3.9148 mL 7.8296 mL 19.5741 mL
10 mM 0.3915 mL 1.9574 mL 3.9148 mL 9.7870 mL
15 mM 0.2610 mL 1.3049 mL 2.6099 mL 6.5247 mL
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Hexadecanamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexadecanamide629-54-9PalmitamideBacterialNF-κBPPARNuclear factor-κBNuclear factor-kappaBPeroxisome proliferator-activated receptorsanti-allergicantioxidantSARA-induced mastitisblood-milk barrier integritysperm motilityInhibitorinhibitorinhibit

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