Sall4 - spalt like transcription factor 4 Gene

Mus musculus

Also known as Tex20; 5730441M18Rik; C330011P20Rik

Gene ID: 99377 | Gene type: protein coding

About Sall4

Summary

This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Sall4 Products(3)

mRNA	Protein	Name
NM_175303.4	NP_780512.2	sal-like protein 4 isoform a
NM_201395.3	NP_958797.2	sal-like protein 4 isoform b
NM_201396.3	NP_958798.2	sal-like protein 4 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16380715	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	26523946	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	16380715	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	16380715	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16380715	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17060609	MGI
acts upstream of or within inner cell mass cell proliferation	IMP IMP: Inferred from mutant phenotype	16790473	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16380715	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	16790473	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	16790473	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	18818376	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16380715	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16380715	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20720539	MGI
acts upstream of or within tissue development	IMP IMP: Inferred from mutant phenotype	17060609	MGI
acts upstream of or within ventricular septum development	IGI IGI: Inferred from genetic interaction	16790473	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	16790473	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	17295837	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19796622	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	19796622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sal-like protein 4

sal-like 4

zinc finger protein SALL4

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144998	NVP-DKY709	Inhibitor	98.86%	Unkown
HY-169348	β-catenin-IN-8	Inhibitor	/	Unkown
HY-RS12420	SALL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21750	Sall4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28268	Sall4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sall4	NCBI	NCBI:57167

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