SLIT2 - slit guidance ligand 2 Gene

Homo sapiens

Also known as SLIL3; Slit-2

Gene ID: 9353 | Gene type: protein coding

About SLIT2

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:20,251,905-20,620,561 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 25 paralogues. Broad expression in lung (RPKM 13.1), adrenal (RPKM 9.9) and 21 other tissues.

Summary

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during Other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as Other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

SLIT2 Products(3)

mRNA	Protein	Name
NM_001289135.3	NP_001276064.1	slit homolog 2 protein isoform 2 precursor
NM_001289136.3	NP_001276065.1	slit homolog 2 protein isoform 3 precursor
NM_004787.4	NP_004778.1	slit homolog 2 protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase inhibitor activity	IDA IDA: Inferred from direct assay	16439689	GOA
enables Roundabout binding	IPI IPI: Inferred from physical interaction	10102268	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	17062560	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19498462	GOA
enables laminin-1 binding	IDA IDA: Inferred from direct assay	10102268	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10102268	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19498462	GOA
enables proteoglycan binding	IPI IPI: Inferred from physical interaction	11375980	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Roundabout signaling pathway	IMP IMP: Inferred from mutant phenotype	18829537	GOA
involved in apoptotic process involved in luteolysis	IEP IEP: Inferred from expression pattern	18566128	GOA
involved in axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	16840550	GOA
involved in axon guidance	IDA IDA: Inferred from direct assay	11748139	GOA
involved in branching morphogenesis of an epithelial tube	IDA IDA: Inferred from direct assay	18345009	GOA
involved in branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	19005219	GOA
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19351956	GOA
involved in cellular response to heparin	IDA IDA: Inferred from direct assay	17062560	GOA
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	18566128	GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	IDA IDA: Inferred from direct assay	11748139	GOA
involved in chemorepulsion involved in postnatal olfactory bulb interneuron migration	IDA IDA: Inferred from direct assay	15207848	GOA
involved in corticospinal neuron axon guidance through spinal cord	IMP IMP: Inferred from mutant phenotype	10975526	GOA
involved in induction of negative chemotaxis	IDA IDA: Inferred from direct assay	10197527	GOA
involved in motor neuron axon guidance	IDA IDA: Inferred from direct assay	10102268	GOA
involved in negative chemotaxis	IDA IDA: Inferred from direct assay	11748139	GOA
involved in negative chemotaxis	IMP IMP: Inferred from mutant phenotype	19005219	GOA
involved in negative regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	19759280	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18829537	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	19005219	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18566128	GOA
involved in negative regulation of cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	16439689	GOA
involved in negative regulation of chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18829537	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	18345009	GOA
involved in negative regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	16439689	GOA
involved in negative regulation of leukocyte chemotaxis	IDA IDA: Inferred from direct assay	11309622	GOA
involved in negative regulation of mononuclear cell migration	IDA IDA: Inferred from direct assay	16439689	GOA
involved in negative regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	19759280	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18345009	GOA
involved in negative regulation of retinal ganglion cell axon guidance	IDA IDA: Inferred from direct assay	17062560	GOA
involved in negative regulation of small GTPase mediated signal transduction	IDA IDA: Inferred from direct assay	16439689	GOA
involved in negative regulation of smooth muscle cell chemotaxis	IDA IDA: Inferred from direct assay	16439689	GOA
involved in negative regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	16439689	GOA
involved in negative regulation of vascular permeability	IDA IDA: Inferred from direct assay	18345009	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18566128	GOA
involved in response to cortisol	IEP IEP: Inferred from expression pattern	18566128	GOA
involved in retinal ganglion cell axon guidance	IDA IDA: Inferred from direct assay	10864954	GOA
involved in ureteric bud development	IMP IMP: Inferred from mutant phenotype	15130495	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10102268	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18566128	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10102268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLIT2 Protein Structure

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

LRRNT

LRR_8

LRRCT

LRRNT

LRR_1

LRR_8

LRRCT

EGF

Laminin_G_1

0
300
600
900
1200
1529 a.a.

Protein Preferred Names

Protein Names

slit homolog 2 protein

SLIT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLIT2	O94813	SLIT2	Homo sapiens	O94813	DLS	19498462
Intra	SLIT2	O94813	SLIT2	Homo sapiens	O94813	X-Ray Diffraction	19498462
Intra	SLIT2	O94813	ROBO1	Homo sapiens	Q9Y6N7	SPR	17848514
Intra	SLIT2	O94813	a0a2u2h391_yerpe	Yersinia pestis	A0A2U2H391	Y2H Pooling	20711500
Intra	SLIT2	O94813	HOXA1	Homo sapiens	P49639	Y2H Pooling	21653829
Intra	SLIT2	O94813	ROBO1	Homo sapiens	Q9Y6N7	X-Ray Diffraction	17848514
Intra	SLIT2	O94813	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Y2H	18985028
Intra	SLIT2	O94813	Q9WMX2-PRO_0000037546	Hepatitis C virus	Q9WMX2-PRO_0000037546	Y2H	18985028
Intra	SLIT2	O94813	bilf1_ebvb9	Epstein-Barr virus	P03208	Y2H	17446270

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Corneal Neovascularization

Corneal Neovascularisation	Corneal Vascularisation
Extensive Superficial Corneal Vascularisation

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146411	microRNA-21-IN-1		98.03%	Unkown
HY-RS13371	SLIT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19035	Slit2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25524	Slit2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLIT2	VGNC	VGNC:77644
Mus musculus	SLIT2	MGD	MGI:1315205
Bos taurus	SLIT2	VGNC	VGNC:34960
Rattus norvegicus	SLIT2	RGD	RGD:69310
Canis familiaris	SLIT2	VGNC	VGNC:46504
Others	SLIT2	NCBI

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