SSH2 - slingshot protein phosphatase 2 Gene

Homo sapiens

Also known as SSH-2; SSH-2L

Gene ID: 85464 | Gene type: protein coding

About SSH2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,625,938-29,930,228 (from NCBI)

This gene has 13 transcripts (splice variants), 264 orthologues and 30 paralogues. Broad expression in lymph node (RPKM 6.2), appendix (RPKM 6.0) and 24 other tissues.

Summary

This gene encodes a protein tyrosine Phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SSH2 Products(4)

mRNA	Protein	Name
NM_001282129.2	NP_001269058.1	protein phosphatase Slingshot homolog 2 isoform 1
NM_001282130.2	NP_001269059.1	protein phosphatase Slingshot homolog 2 isoform 3
NM_001282131.2	NP_001269060.1	protein phosphatase Slingshot homolog 2 isoform 4
NM_033389.3	NP_203747.2	protein phosphatase Slingshot homolog 2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	11832213	GOA
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	11832213	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11832213	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	11832213	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSH2 Protein Structure

DEK_C

DSPc

0
300
600
900
1200
1423 a.a.

Protein Preferred Names

Protein Names

protein phosphatase Slingshot homolog 2

SSH-like protein 2

SSH2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSH2	Q76I76	HECTD1	Homo sapiens	Q9ULT8	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Renal Oncocytoma

Melanotic Medulloblastoma

Medulloblastoma, Melanotic

Nephronophthisis 1

NPHP1	Nephronophthisis, Familial Juvenile
Nph1	Nephronophthisis 1, Juvenile
Juvenile Nephronophthisis 1	Familial Juvenile Nephronophthisis 1
Nephronophthisis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13810	SSH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSH2	VGNC	VGNC:46832
Felis catus	SSH2	VGNC	VGNC:65704
Rattus norvegicus	SSH2	RGD	RGD:1309389
Macaca mulatta	SSH2	VGNC	VGNC:78018
Bos taurus	SSH2	VGNC	VGNC:35313
Mus musculus	SSH2	MGD	MGI:2679255

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