ZCRB1 - zinc finger CCHC-type and RNA binding motif containing 1 Gene

Homo sapiens

Also known as MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19

Gene ID: 85437 | Gene type: protein coding

About ZCRB1

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:42,312,086-42,326,094 (from NCBI)

This gene has 12 transcripts (splice variants), 249 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 32.6), brain (RPKM 19.2) and 25 other tissues.

Summary

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many Other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

ZCRB1 Products(1)

mRNA	Protein	Name
NM_033114.4	NP_149105.3	zinc finger CCHC-type and RNA-binding motif-containing protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZCRB1 Protein Structure

RRM_1

zf-CCHC

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

zinc finger CCHC-type and RNA-binding motif-containing protein 1

U11/U12 small nuclear ribonucleoprotein 31 kDa protein

ZCRB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZCRB1	Q8TBF4	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	ZCRB1	Q8TBF4	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	ZCRB1	Q8TBF4	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	ZCRB1	Q8TBF4	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ZCRB1	Q8TBF4	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ZCRB1	Q8TBF4	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ZCRB1	Q8TBF4	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	ZCRB1	Q8TBF4	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	ZCRB1	Q8TBF4	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Conjunctival Folliculosis

Acute Follicular Conjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16008	ZCRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZCRB1	VGNC	VGNC:48574
Rattus norvegicus	ZCRB1	RGD	RGD:1309851
Macaca mulatta	ZCRB1	VGNC	VGNC:100124
Mus musculus	ZCRB1	MGD	MGI:1914447
Bos taurus	ZCRB1	VGNC	VGNC:37124

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