USP38 - ubiquitin specific peptidase 38 Gene

Homo sapiens

Also known as HP43.8KD

Gene ID: 84640 | Gene type: protein coding

About USP38

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:143,184,917-143,223,874 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 7.3), colon (RPKM 5.9) and 25 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP38 Products(4)

mRNA	Protein	Name
NM_001290325.1	NP_001277254.1	ubiquitin carboxyl-terminal hydrolase 38 isoform 2
NM_001290326.1	NP_001277255.1	ubiquitin carboxyl-terminal hydrolase 38 isoform 3
NM_001410848.1	NP_001397777.1	ubiquitin carboxyl-terminal hydrolase 38 isoform 4
NM_032557.6	NP_115946.2	ubiquitin carboxyl-terminal hydrolase 38 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	14715245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	34102342	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	27692986	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34102342	GOA
involved in protein K33-linked deubiquitination	IDA IDA: Inferred from direct assay	27692986	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	27692986	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP38 Protein Structure

UCH

0
200
400
600
800
1042 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 38

deubiquitinating enzyme 38

USP38 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP38	Q8NB14	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	USP38	Q8NB14	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	USP38	Q8NB14	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	USP38	Q8NB14	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	USP38	Q8NB14	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	USP38	Q8NB14	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	USP38	Q8NB14	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	USP38	Q8NB14	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	USP38	Q8NB14	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	USP38	Q8NB14	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	USP38	Q8NB14	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	USP38	Q8NB14	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15549	USP38 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19493	Usp38 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25987	Usp38 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USP38	VGNC	VGNC:48193
Macaca mulatta	USP38	VGNC	VGNC:79224
Felis catus	USP38	VGNC	VGNC:66884
Bos taurus	USP38	VGNC	VGNC:36727
Mus musculus	USP38	MGD	MGI:1922091
Rattus norvegicus	USP38	RGD	RGD:1311974

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