2. Gene
  3. Tcf4 - transcription factor 4 Gene

Tcf4 - transcription factor 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84382 | Gene type: protein coding

About Tcf4

Summary

Enables bHLH transcription factor binding activity and double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleus. Predicted to be part of beta-catenin-TCF7L2 complex. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tcf4 Products(1)

mRNA Protein Name
NM_053369.2 NP_445821.2 transcription factor 4
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
15831523 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
7913462 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7913462 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 4

ITF-2

R8f DNA-binding protein

RITF-2

SEF-2

SL3-3 enhancer factor 2

TCF-4

immunoglobulin transcription factor 2

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1360 Chlorquinaldol 98.69% Unkown
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101486 LF3 Antagonist 99.55% Unkown
HY-100760 Toxoflavin Inhibitor 99.88% Unkown
HY-P10392B aStAx-35R TFA 99.18% Unkown
HY-119966 CCT036477 Inhibitor 99.42% Unkown
HY-100760S Toxoflavin-13C4 Inhibitor / Unkown
HY-124826 BC21 Inhibitor / Unkown
HY-149858 β-catenin-IN-7 Inhibitor / Unkown
HY-157126 Pterostilbene-isothiocyanate Inhibitor / Unkown
HY-172393 TCF4/β-catenin-IN-1 / Unkown
HY-P10392 aStAx-35R / Unkown
HY-RS14307 TCF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14310 TCF7L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17416 Tcf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17858 Tcf7l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23870 Tcf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf4 NCBI NCBI:6925