Gabbr2 - gamma-aminobutyric acid type B receptor subunit 2 Gene

Rattus norvegicus

Also known as Gpr51

Gene ID: 83633 | Gene type: protein coding

About Gabbr2

Summary

Enables G protein-coupled GABA Receptor activity. Involved in gamma-aminobutyric acid signaling pathway and neuron-glial cell signaling. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 59 and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Gabbr2 Products(1)

mRNA	Protein	Name
NM_031802.2	NP_113990.2	gamma-aminobutyric acid type B receptor subunit 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled GABA receptor activity	IDA IDA: Inferred from direct assay	11389174	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19590495	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15147298	RGD
involved in gamma-aminobutyric acid signaling pathway	IDA IDA: Inferred from direct assay	11389174	RGD
involved in neuron-glial cell signaling	IGI IGI: Inferred from genetic interaction	10196584	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	14657159	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14657159	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14657159	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14657159	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid type B receptor subunit 2

G-protein coupled receptor 51	GABA-B R2 receptor
GABA-B receptor 2	GABA-B-R2
GABA-BR2	GABABR2
gamma-aminobutyric acid (GABA) B receptor 2	gb2

Gabbr2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gabbr2	O88871	Gabbr1	Rattus norvegicus	Q9Z0U4	Anti Tag CoIP	19590495
Intra	Gabbr2	O88871	Gabbr1	Rattus norvegicus	Q9Z0U4	FRET	19590495
Intra	Gabbr2	O88871	Gabbr1	Rattus norvegicus	Q9Z0U4	BRET	19590495
Intra	Gabbr2	O88871	Gabbr1	Rattus norvegicus	Q9Z0U4	Anti Tag CoIP	21552208
Intra	Gabbr2	O88871	Cacna1d	Rattus norvegicus	P27732	Anti Bait CoIP	20627102
Intra	Gabbr2	O88871	Cacna1d	Rattus norvegicus	P27732	Y2H	20627102
Intra	Gabbr2	O88871	Cacna1d	Rattus norvegicus	P27732	Pull Down	20627102

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05205	GABBR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabbr2	NCBI	NCBI:9568

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