Gabbr1 - gamma-aminobutyric acid type B receptor subunit 1 Gene

Rattus norvegicus

Gene ID: 81657 | Gene type: protein coding

About Gabbr1

Summary

Enables G protein-coupled GABA Receptor activity; extracellular matrix protein binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of Adenylate Cyclase activity; neuron-glial cell signaling; and regulation of secretion. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in several cellular components, including axolemma; dendrite; and synaptic vesicle. Is integral component of plasma membrane. Part of GABA Receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study visual epilepsy. Biomarker of hypertension and visual epilepsy. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Gabbr1 Products(1)

mRNA	Protein	Name
NM_031028.3	NP_112290.2	gamma-aminobutyric acid type B receptor subunit 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled GABA receptor activity	IDA IDA: Inferred from direct assay	10457184	RGD
enables G protein-coupled GABA receptor activity	IMP IMP: Inferred from mutant phenotype	12054677	RGD
enables extracellular matrix protein binding	IMP IMP: Inferred from mutant phenotype	15304491	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15304491	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	15304491	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9069281	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15147298	RGD
involved in gamma-aminobutyric acid signaling pathway	IDA IDA: Inferred from direct assay	15147298	RGD
involved in negative regulation of adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	15147298	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15147298	RGD
involved in negative regulation of dopamine secretion	IDA IDA: Inferred from direct assay	12872287	RGD
involved in negative regulation of epinephrine secretion	IMP IMP: Inferred from mutant phenotype	14568556	RGD
involved in negative regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	14654095	RGD
involved in negative regulation of synaptic transmission	IDA IDA: Inferred from direct assay	12604336	RGD
involved in neuron-glial cell signaling	IGI IGI: Inferred from genetic interaction	10196584	RGD
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	12054677	RGD
involved in positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	18765663	RGD
involved in positive regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	12218349	RGD
involved in regulation of glutamate secretion	IDA IDA: Inferred from direct assay	15561437	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16246313	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	12435490	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of GABA receptor complex	IDA IDA: Inferred from direct assay	15304491	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	14657159	RGD
located in axolemma	IDA IDA: Inferred from direct assay	17924569	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	17241134	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16983643	RGD
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17924569	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	18765663	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14657159	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	17924569	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17241134	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15304491	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14657159	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14657159	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	15304491	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	17924569	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid type B receptor subunit 1

GABA-B receptor 1	GABA-B-R1
GABA-BR1	GABABR1
gamma-aminobutyric acid (GABA) B receptor 1	gb1

Gabbr1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gabbr1	Q9Z0U4	Gabbr2	Rattus norvegicus	O88871	FRET	21552208
Intra	Gabbr1	Q9Z0U4	Gabbr2	Rattus norvegicus	O88871	Anti Tag CoIP	19590495
Intra	Gabbr1	Q9Z0U4	Gabbr2	Rattus norvegicus	O88871	FRET	21063387
Intra	Gabbr1	Q9Z0U4	Gabbr2	Rattus norvegicus	O88871	FRET	19590495

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05204	GABBR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabbr1	NCBI	NCBI:2550

Name
Email *

	Sorry, but the email address you supplied was invalid.