Cacna1d - calcium voltage-gated channel subunit alpha1 D Gene

Rattus norvegicus

Gene ID: 29716 | Gene type: protein coding

About Cacna1d

Summary

Enables PDZ domain binding activity; ankyrin binding activity; and high voltage-gated Calcium Channel activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of CREB transcription factor activity; and positive regulation of transport. Located in several cellular components, including apical plasma membrane; dendrite membrane; and sarcolemma. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1d Products(1)

mRNA	Protein	Name
NM_001389225.2	NP_001376154.1	voltage-dependent L-type calcium channel subunit alpha-1D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	17287512	RGD
enables ankyrin binding	IPI IPI: Inferred from physical interaction	21859974	RGD
enables high voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	18322004	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20627102	RGD
enables voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	11487617	RGD
enables voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	17050707	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion import	IMP IMP: Inferred from mutant phenotype	16706838	RGD
involved in calcium ion transport	IDA IDA: Inferred from direct assay	21859974	RGD
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	7479909	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	21822937	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	21378599	RGD
involved in memory	IEP IEP: Inferred from expression pattern	12591156	RGD
involved in metal ion transport	IMP IMP: Inferred from mutant phenotype	17287512	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in positive regulation of CREB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16706838	RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP IMP: Inferred from mutant phenotype	25675390	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	23229155	RGD
involved in positive regulation of membrane depolarization	IDA IDA: Inferred from direct assay	7760845	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	21859974	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19593990	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14637163	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21822937	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	16706838	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	19136044	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	19665524	RGD
located in primary dendrite	IDA IDA: Inferred from direct assay	19136044	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	21378599	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-dependent L-type calcium channel subunit alpha-1D

CaV1.3alpha1	RBD
brain class D	calcium channel alpha-1 subunit
calcium channel, L type, alpha-1 polypeptide	calcium channel, voltage-dependent, L type, alpha 1D subunit
voltage-dependent calcium channel subunit alpha1D	voltage-gated calcium channel

Cacna1d Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cacna1d	P27732	Gabbr2	Rattus norvegicus	O88871	Pull Down	20627102
Intra	Cacna1d	P27732	Gabbr2	Rattus norvegicus	O88871	IF	20627102
Intra	Cacna1d	P27732	Gabbr2	Rattus norvegicus	O88871	Anti Bait CoIP	20627102

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01794	CACNA1D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20625	Cacna1d Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27134	Cacna1d Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cacna1d	NCBI	NCBI:776

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