Lamtor2 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Gene

Mus musculus

Also known as P14; Rab25; Robld3; Mapbpip; 2010111E04Rik

Gene ID: 83409 | Gene type: protein coding

About Lamtor2

Summary

Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Acts upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Located in late endosome. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and mTOR Activator 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamtor2 Products(2)

mRNA	Protein	Name
NM_001362368.1	NP_001349297.1	ragulator complex protein LAMTOR2 isoform 2
NM_031248.4	NP_112538.1	ragulator complex protein LAMTOR2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15263099	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within fibroblast migration	IDA IDA: Inferred from direct assay	24841562	MGI
acts upstream of or within fibroblast migration	IGI IGI: Inferred from genetic interaction	24841562	MGI
acts upstream of or within fibroblast migration	IMP IMP: Inferred from mutant phenotype	24841562	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15263099	MGI
acts upstream of or within protein localization to cell junction	IMP IMP: Inferred from mutant phenotype	24841562	MGI
acts upstream of or within regulation of cell-substrate junction organization	IDA IDA: Inferred from direct assay	24841562	MGI
acts upstream of or within regulation of cell-substrate junction organization	IMP IMP: Inferred from mutant phenotype	24841562	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in late endosome	IDA IDA: Inferred from direct assay	15263099	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ragulator complex protein LAMTOR2

endosomal adaptor protein p14	late endosomal/lysosomal MP1 interacting protein
late endosomal/lysosomal adaptor and MAPK and MTOR activator 2	mitogen-activated protein-binding protein-interacting protein
roadblock domain-containing protein 3

Lamtor2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lamtor2	Q9JHS3	Lamtor3	Mus musculus	O88653	X-Ray Diffraction	15263099
Cross	Lamtor2	Q9JHS3	Lamtor1	Rattus norvegicus	Q6P791	IF	19177150

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07514	LAMTOR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19544	Lamtor2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26040	Lamtor2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lamtor2	NCBI	NCBI:28956

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