2. Gene
  3. Tfap4 - transcription factor AP4 Gene

Tfap4 - transcription factor AP4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AP-4; Tcfap4; bHLHc41; D930048N17Rik

Gene ID: 83383 | Gene type: protein coding

About Tfap4

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in cellular response to dexamethasone stimulus; negative regulation of macromolecule metabolic process; and protein-containing complex assembly. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and gut. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]

Tfap4 Products(1)

mRNA Protein Name
NM_031182.2 NP_112459.1 transcription factor AP-4
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15944155 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15944155 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15944155 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15944155 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15944155 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor AP-4

transcription factor AP-4 (activating enhancer-binding protein 4)

Tfap4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Tfap4 Q9JIZ5 Gmnn Mus musculus O88513
Anti Tag CoIP
16924111
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-173482 TFAP4/Wnt/β-catenin-IN-1 Inhibitor / Unkown
HY-RS14412 TFAP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21784 Tfap4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfap4 NCBI NCBI:7023