2. Gene
  3. Pnpt1 - polyribonucleotide nucleotidyltransferase 1 Gene

Pnpt1 - polyribonucleotide nucleotidyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Old35; PNPase; Pnptl1; 1200003F12Rik

Gene ID: 71701 | Gene type: protein coding

About Pnpt1

Summary

Predicted to enable 3'-5'-exoribonuclease activity; RNA binding activity; and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrion morphogenesis; and regulation of cellular respiration. Located in mitochondrial intermembrane space. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70 and combined Oxidative Phosphorylation deficiency 13. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pnpt1 Products(1)

mRNA Protein Name
NM_027869.2 NP_082145.1 polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
20691904 MGI
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
16966381 MGI
involved in regulation of cellular respiration IMP
IMP: Inferred from mutant phenotype
16966381 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
16966381 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16966381 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyribonucleotide nucleotidyltransferase 1, mitochondrial

3'-5' RNA exonuclease OLD35

PNPase 1

PNPase old-35

polynucleotide phosphorylase 1

polynucleotide phosphorylase-like protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10801 PNPT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21028 Pnpt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27545 Pnpt1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnpt1 NCBI NCBI:87178