Gsdmd - gasdermin D Gene

Mus musculus

Also known as DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik

Gene ID: 69146 | Gene type: protein coding

About Gsdmd

Summary

Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]

Gsdmd Products(1)

mRNA	Protein	Name
NM_026960.4	NP_081236.1	gasdermin-D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cardiolipin binding	IDA IDA: Inferred from direct assay	27383986	MGI
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	27383986	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	27383986	MGI
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	27383986	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	27383986	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	37327784	MGI
enables wide pore channel activity	IDA IDA: Inferred from direct assay	27339137	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to stimulus	IDA IDA: Inferred from direct assay	10322635	MGI
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	27383986	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	37988464	MGI
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	27383986	MGI
involved in pore complex assembly	IDA IDA: Inferred from direct assay	27383986	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	27383986	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	26611636	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	27383986	MGI
involved in protein secretion	IDA IDA: Inferred from direct assay	35705808	MGI
involved in pyroptotic cell death	IDA IDA: Inferred from direct assay	27339137	MGI
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	26611636	MGI
involved in pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	37988464	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLRP3 inflammasome complex	IDA IDA: Inferred from direct assay	26611636	MGI
located in cytosol	IDA IDA: Inferred from direct assay	27383986	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	27383986	MGI
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	37001519	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	27339137	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	27339137	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gasdermin-D

gasdermin domain containing 1	gasdermin domain-containing protein 1
gasderminD-1

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0240	Disulfiram		99.77%	Unkown
HY-B0240R	Disulfiram (Standard)		99.54%	Unkown

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13453	BAY 11-7082		99.98%	Unkown
HY-100381	Nigericin sodium salt		99.37%	Unkown
HY-127019	Nigericin		99.43%	Unkown
HY-100573	Necrosulfonamide		99.47%	Unkown
HY-111674	LDC7559	Inhibitor	99.51%	Unkown
HY-N0816	Polyphyllin VI		98.49%	Unkown
HY-171006	IRF1-IN-1	Inhibitor	99.72%	Unkown
HY-111675	Ac-FLTD-CMK	Inhibitor	99.18%	Unkown
HY-N2414	Periplogenin		≥99.70%	Unkown
HY-W075517	ZIF-8		/	Unkown
HY-152670	JC2-11	Inhibitor	98.03%	Unkown
HY-171007	IRF1-IN-2		99.83%	Unkown
HY-N0218	Benzoylmesaconine	Inhibitor	99.56%	Unkown
HY-RS05857	GSDMD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100573A	(E/Z)-Necrosulfonamide		98.84%	Unkown
HY-156374	D359-0396	Inhibitor	99.98%	Unkown
HY-161727	P2Y14R antagonist 1		98.58%	Unkown
HY-100573S	Necrosulfonamide-d4		99.26%	Unkown
HY-130480	Fructose-arginine	Inhibitor	98.32%	Unkown
HY-RS16519	Gsdmd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-161332	Antitumor agent-143		/	Unkown
HY-172788	NLRP3-IN-78	Inhibitor	/	Unkown
HY-173234	GI-Y2	Inhibitor	/	Unkown
HY-175640	Troponin-IN-1	Inhibitor	/	Unkown
HY-RS22950	Gsdmd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsdmd	NCBI	NCBI:79792

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