Mesd - mesoderm development LRP chaperone Gene

Mus musculus

Also known as msd; mesd; Mesdc2; mKIAA0081; 2210015O11Rik

Gene ID: 67943 | Gene type: protein coding

About Mesd

Summary

Enables identical protein binding activity and low-density lipoprotein particle receptor binding activity. Involved in phagocytosis and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within protein folding and protein localization to cell surface. Located in plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and ventricular layer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Orthologous to human MESD (mesoderm development LRP chaperone). [provided by Alliance of Genome Resources, Apr 2022]

Mesd Products(2)

mRNA	Protein	Name
NM_001374090.1	NP_001361019.1	LRP chaperone MESD isoform 2
NM_023403.4	NP_075892.3	LRP chaperone MESD isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21397184	MGI
enables low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	16263759	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16989816	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	27184668	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	24140340	MGI
acts upstream of or within protein folding	IDA IDA: Inferred from direct assay	16263759	MGI
involved in protein folding	IMP IMP: Inferred from mutant phenotype	21397183	MGI
acts upstream of or within protein localization to cell surface	IDA IDA: Inferred from direct assay	18505367	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16263759	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

LRP chaperone MESD

LDLR chaperone MESD

mesoderm development candidate 2

Mesd Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mesd	Q9ERE7	LRP5	Homo sapiens	O75197	Anti Tag CoIP	15143163
Intra	Mesd	Q9ERE7	Lrp5	Mus musculus	Q91VN0	Anti Tag CoIP	12581525
Intra	Mesd	Q9ERE7	Mesd	Mus musculus	Q9ERE7	Solution Sedimentation	21397184
Intra	Mesd	Q9ERE7	Mesd	Mus musculus	Q9ERE7	X-Ray Diffraction	21397184
Cross	Mesd	Q9ERE7	LRP6	Homo sapiens	O75581	Anti Tag CoIP	16989816
Intra	Mesd	Q9ERE7	Lrp6	Mus musculus	O88572	Anti Tag CoIP	12581525
Intra	Mesd	Q9ERE7	Mesd	Mus musculus	Q9ERE7	GMS	21397184

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0858S	MES-d13		98.78%	Unkown
HY-RS08341	MESD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19918	Mesd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26419	Mesd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mesd	NCBI	NCBI:23184

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