2. Gene
  3. Nmnat1 - nicotinamide nucleotide adenylyltransferase 1 Gene

Nmnat1 - nicotinamide nucleotide adenylyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as nmnat; D4Cole1e; 2610529L11Rik; 5730441G13Rik

Gene ID: 66454 | Gene type: protein coding

About Nmnat1

Summary

Enables nicotinamide-nucleotide adenylyltransferase activity and nicotinate-nucleotide adenylyltransferase activity. Involved in negative regulation of neuron death. Acts upstream of or within NAD biosynthetic process and response to wounding. Located in nucleus. Used to study Leber congenital amaurosis 9 and retinal degeneration. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nmnat1 Products(2)

mRNA Protein Name
NM_001356357.1 NP_001343286.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
NM_133435.2 NP_597679.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nicotinamide-nucleotide adenylyltransferase activity IDA
IDA: Inferred from direct assay
16914673 MGI
enables nicotinate-nucleotide adenylyltransferase activity IDA
IDA: Inferred from direct assay
15381699 MGI
enables protein ADP-ribosyltransferase-substrate adaptor activity IDA
IDA: Inferred from direct assay
32822587 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within NAD biosynthetic process IDA
IDA: Inferred from direct assay
15381699 MGI
involved in NAD biosynthetic process IMP
IMP: Inferred from mutant phenotype
27735788 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
32822587 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
16914673 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in chromatin IDA
IDA: Inferred from direct assay
32822587 MGI
located in chromatin IDA
IDA: Inferred from direct assay
32822587 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15381699 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

NMN adenylyltransferase 1

NMN/NaMN adenylyltransferase 1

naMN adenylyltransferase 1

nicotinamide mononucleotide adenylyl transferase

nicotinamide mononucleotide adenylyltransferase 1

nicotinamide/nicotinate mononucleotide adenylyltransferase 1

nicot

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W615108B β-Nicotinamide mononucleotide, reduced form disodium 99.55% Unkown
HY-161712 Nampt-IN-12 Inhibitor 99.76% Unkown
HY-RS09382 NMNAT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18008 Nmnat1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24481 Nmnat1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nmnat1 NCBI NCBI:64802