Syt9 - synaptotagmin IX Gene

Mus musculus

Gene ID: 60510 | Gene type: protein coding

About Syt9

Summary

Enables SNARE binding activity; identical protein binding activity; and phospholipid binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion and regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is integral component of synaptic vesicle membrane. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adrenal gland; gonad; liver; nervous system; and spleen. Orthologous to human SYT9 (synaptotagmin 9). [provided by Alliance of Genome Resources, Apr 2022]

Syt9 Products(1)

mRNA	Protein	Name
NM_021889.4	NP_068689.2	synaptotagmin-9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	10531343	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10531343	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium-dependent activation of synaptic vesicle fusion	IDA IDA: Inferred from direct assay	17521570	MGI
involved in calcium-dependent activation of synaptic vesicle fusion	IMP IMP: Inferred from mutant phenotype	17521570	MGI
involved in regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	12860971	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dense core granule	IDA IDA: Inferred from direct assay	16407767	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	17521570	MGI
is active in hippocampal mossy fiber to CA3 synapse	IEP IEP: Inferred from expression pattern	17521570	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	17521570	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17521570	MGI
is active in synaptic vesicle membrane	IEP IEP: Inferred from expression pattern	17521570	MGI
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	17521570	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptotagmin-9

synaptotagmin V

sytIX

Syt9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Syt9	Q9R0N9	Syt3	Mus musculus	O35681	Comigration in SDS	10531343
Intra	Syt9	Q9R0N9	Syt10	Mus musculus	Q9R0N4	Comigration in SDS	10531343
Intra	Syt9	Q9R0N9	Syt9	Mus musculus	Q9R0N9	Comigration in SDS	10531343
Intra	Syt9	Q9R0N9	Wnk1	Rattus norvegicus	Q9JIH7	Y2H	15350218

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14121	SYT9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt9	NCBI	NCBI:143425

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