Syt10 - synaptotagmin X Gene

Mus musculus

Gene ID: 54526 | Gene type: protein coding

About Syt10

Summary

Enables several functions, including SNARE binding activity; phospholipid binding activity; and protein dimerization activity. Involved in chemical synaptic transmission; positive regulation of calcium ion-dependent exocytosis; and sensory perception of smell. Located in exocytic vesicle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; ear; and skeleton. Orthologous to human SYT10 (synaptotagmin 10). [provided by Alliance of Genome Resources, Apr 2022]

Syt10 Products(1)

mRNA	Protein	Name
NM_018803.2	NP_061273.1	synaptotagmin-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	21496647	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	10531343	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10531343	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10531344	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10531343	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21496647	MGI
involved in positive regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	21496647	MGI
involved in presynaptic dense core vesicle exocytosis	IDA IDA: Inferred from direct assay	28683263	MGI
involved in presynaptic dense core vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	28683263	MGI
involved in regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	12860971	MGI
involved in sensory perception of smell	IMP IMP: Inferred from mutant phenotype	21496647	MGI
NOT involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	21496647	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in exocytic vesicle	IDA IDA: Inferred from direct assay	21496647	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28683263	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28683263	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	28683263	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptotagmin-10

sytX

Syt10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Syt10	Q9R0N4	Syt3	Mus musculus	O35681	Comigration in SDS	10531343
Intra	Syt10	Q9R0N4	Syt9	Mus musculus	Q9R0N9	Comigration in SDS	10531343
Intra	Syt10	Q9R0N4	Syt10	Mus musculus	Q9R0N4	Comigration in SDS	10531343

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14107	SYT10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt10	NCBI	NCBI:341359

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