2. Gene
  3. SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT

Gene ID: 57152 | Gene type: protein coding

About SLURP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,740,949-142,742,406 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward esophagus (RPKM 167.7).

Summary

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

SLURP1 Products(1)

mRNA Protein Name
NM_020427.3 NP_065160.1 secreted Ly-6/uPAR-related protein 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholine receptor activator activity IDA
IDA: Inferred from direct assay
14506129 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25168896 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
25168896 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
25168896 GOA
involved in urokinase plasminogen activator signaling pathway IDA
IDA: Inferred from direct assay
25168896 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
25919322 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLURP1 Protein Structure

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (25 - 100)

  • 0
  • 103 a.a.
Protein Preferred Names Protein Names

secreted Ly-6/uPAR-related protein 1

ARS(component B)-81/S

SLURP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLURP1 P55000 PLAU Homo sapiens P00749
Anti Tag CoIP
33961781
Intra
SLURP1 P55000 PLAU Homo sapiens P00749
ELISA
25168896
Intra
SLURP1 P55000 CHRNA7 Homo sapiens P36544
Affinity Chrom
26905431
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mal De Meleda

Meleda Disease

Keratosis Palmoplantaris Transgrediens Of Siemens

MDM

Transgrediens Palmoplantar Keratoderma Of Siemens

Acroerythrokeratoderma

Keratosis Palmoplantaris Transgradiens Of Siemens
Palmoplantar Keratoderma, Norrbotten Recessive Type

PPKNR

Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type

Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type

Ppk, Gamborg-Nielsen Type

Keratoderma, Palmoplantar, Norrbotten Recessive Type
Palmoplantar Keratosis

Palmoplantar Keratoderma

Keratosis Palmaris Et Plantaris

Palmo-Plantar Keratodermas

Keratoderma, Palmoplantar

Keratoderma Palmoplantar

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis Of Palms And Soles

Palmoplantar Hyperkeratosis
Necrotizing Ulcerative Gingivitis

Acute Necrotizing Ulcerative Gingivitis

Anug

Vincent Angina

Vincent'S Disease

Acute Necrotising Ulcerative Gingivitis

Acute Necrotising Ulcerative Gingivostomatitis

Acute Necrotizing Ulcerative Gingivostomatitis

Acute Ulceromembranous Gingivitis

Angina - Vincents

Early Acute Necrotising Gingivitis

Trench Mouth

Vincent'S Angina

Vincent'S Angina - Pharyngitis

Vincent'S Infection, Any Site

Acute Membranous Gingivitis

Fusospirillary Gingivitis

Fusospirillosis

Phagedenic Gingivitis

Vincent'S Gingivitis

Vincent'S Infection

Vincent'S Stomatitis

Gingivitis, Necrotizing Ulcerative
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma

Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma

FNEPPK1

Ppkfne

Keratoderma, Focal Nonepidermolytic Palmoplantar

Palmoplantar Keratoderma, Nonepidermolytic, Focal

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Fneppk

Focal Nonepidermolytic Palmoplantar Keratoderma 1

Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1

Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis

Erythrokeratodermia Variabilis Et Progressiva

Greither Disease

Ekv

Ekvp

PSEK

Erythrokeratodermia Variabilis With Erythema Gyratum Repens

Keratosis Palmoplantaris Transgrediens Et Progrediens

Transgrediens Et Progrediens Palmoplantar Keratoderma

EKVP1

Erythrokeratodermia, Progressive Symmetric

Erythrokeratodermia Figurata, Congenital Familial, In Plaques

Keratoderma Palmoplantaris Transgrediens

Keratosis Extremitatum Hereditaria Progrediens

Erythrokeratodermia Variabilis, Mendes Da Costa Type

Progressive Symmetric Erythrokeratodermia

Erythrokeratodermia Figurata Variabilis

Greither'S Disease

Ekv-P

Erythrokeratodermia Variabilis Of Mendes Da Costa

Progressive Symmetrical Erythrokeratoderma Of Gottron

Progressive Diffuse Ppk

Progressive Diffuse Palmoplantar Keratoderma

Transgrediens Et Progrediens Ppk

Darier-Gottron Disease

Erythrokeratodermia Progressiva Symmetrica

Progressive Symmetric Erythrokeratodermia, Gottron Type

Congenital Familial Erythrokeratodermia Figurata In Plaques

Erythrokeratodermia Progressive Symmetric

Erythrokeratodermia Variabilis Mendes Da Costa Type
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome

Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

Palmoplantar And Periorificial Keratoderma

Olms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13385 SLURP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLURP1 VGNC VGNC:81699
Rattus norvegicus SLURP1 RGD RGD:1308768
Bos taurus SLURP1 VGNC VGNC:34972
Canis familiaris SLURP1 VGNC VGNC:46516
Macaca mulatta SLURP1 VGNC VGNC:82242
Mus musculus SLURP1 MGD MGI:1930923