MESP1 - mesoderm posterior bHLH transcription factor 1 Gene

Homo sapiens

Also known as bHLHc5

Gene ID: 55897 | Gene type: protein coding

About MESP1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,732,446-89,751,249 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 2 paralogues. Biased expression in fat (RPKM 4.6), prostate (RPKM 4.1) and 4 other tissues.

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including endothelial cell differentiation; heart development; and positive regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MESP1 Products(1)

mRNA	Protein	Name
NM_018670.4	NP_061140.1	mesoderm posterior protein 1

MESP1 Protein Structure

HLH

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

mesoderm posterior protein 1

class C basic helix-loop-helix protein 5

MESP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MESP1	Q9BRJ9	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

MESP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85278	MESP1 Antibody (YA4970)	WB, ELISA	Human

Related Diseases

Diseases

Alias

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Cardiomyopathy, Dilated, 1x

Dilated Cardiomyopathy 1x	CMD1X
Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness	Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness
Cardiomyopathy, Dilated 1x	Cardiomyopathy, Dilated, Type 1x

Mongolian Spot

Mongolian Macula

Dysostosis

Dysostoses

Hypoplastic Left Heart Syndrome

Hlhs	Heart, Hypoplastic Left, Syndrome
Hypoplasia Of The Left Heart	Left Heart Hypoplasia Syndrome
Hlhs - [Hypoplastic Left Heart Syndrome]	Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome
Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome	Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle
Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia	Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome
Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Ventricular Septal Defect

Ventricular Septal Defects	Interventricular Septal Defect
Heart Septal Defects, Ventricular	Ventricular Septal Abnormality
Interventricular Septum Defect	Ventricular Septum Defect
Vsd - [Ventricular Septum Defect]	Congenital Ventricular Septal Defect
Single Ventricular Septal Defect

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08342	MESP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20447	Mesp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26956	Mesp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MESP1	VGNC	VGNC:63453
Macaca mulatta	MESP1	VGNC	VGNC:74618
Canis familiaris	MESP1	VGNC	VGNC:43163
Mus musculus	MESP1	MGD	MGI:107785
Rattus norvegicus	MESP1	RGD	RGD:1311751
Bos taurus	MESP1	VGNC	VGNC:106820

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