Irf7 - interferon regulatory factor 7 Gene

Mus musculus

Gene ID: 54123 | Gene type: protein coding

About Irf7

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to Other organism; positive regulation of transcription, DNA-templated; and regulation of Toll-like Receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Irf7 Products(3)

mRNA	Protein	Name
NM_001252600.1	NP_001239529.1	interferon regulatory factor 7 isoform 2
NM_001252601.1	NP_001239530.1	interferon regulatory factor 7 isoform 3
NM_016850.3	NP_058546.1	interferon regulatory factor 7 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22095711	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	27129230	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27129230	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16236719	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27129230	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	15800576	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27129230	MGI
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	22095711	MGI
acts upstream of or within positive regulation of type I interferon production	IGI IGI: Inferred from genetic interaction	23956435	MGI
acts upstream of or within positive regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17618271	MGI
involved in regulation of MyD88-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15800576	MGI
involved in regulation of MyD88-independent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15800576	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	23160154	MGI
acts upstream of or within type I interferon production	IMP IMP: Inferred from mutant phenotype	15800576	MGI
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27129230	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon regulatory factor 7

IRF-7

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-176426	Subquinocin		/	Phase 4

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117066	CL075	Agonist	99.18%	Unkown
HY-122891	SB02024		99.70%	Unkown
HY-RS06911	IRF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16952	Irf7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23395	Irf7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irf7	NCBI	NCBI:3665

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